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Purpose This primary objective of this phase I dose-escalation study was to define the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of larotaxel administered in combination with carboplatin in chemotherapy-naïve patients with advanced/metastatic non-small cell lung cancer (NSCLC). Methods Eighteen patients with stage IIIB or IV NSCLC, in cohorts of three to six evaluable patients,...