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Summary Long-term treatment with 200 mg dry weight/day of pamidronate (APD) by oral route has been proposed to increase bone mineral density (BMD) in postmenopausal osteoporotic women. However, there is widespread concern over the possibility of bone metabolism “freezing” by protracted use of medication liable to inhibit bone resorption. Accordingly, an open population of 39 osteoporotic women was...