Search results for: Joanne C. Mockler

Items from 1 to 11 out of 11 results

article

Effects of foetal growth restriction and preterm birth on cardiac morphology and function during infancy

Emily Cohen, Christie Whatley, Flora Y. Wong, Euan M. Wallace, more

Aim To investigate the effects of foetal growth restriction (FGR) and prematurity on cardiac morphology and function in infancy. We hypothesised that FGR and prematurity would both alter cardiac development. Methods Cardiac morphology and function were evaluated in 24 preterm FGR infants (p‐FGR) and 23 preterm and 19 term appropriately grown for gestational age infants (p‐AGA and t‐AGA, respectively)...

article

EEG power spectrum maturation in preterm fetal growth restricted infants

Emily Cohen, Flora Y. Wong, Euan M. Wallace, Joanne C. Mockler, more

Brain Research > 2018 > 1678 > C > 180-186

Power spectral analysis of the electroencephalogram (EEG) is a non-invasive method to examine infant brain maturation. Preterm fetal growth restricted (p-FGR) neonates display an altered EEG power spectrum compared to appropriate-for-gestational-age (AGA) peers, suggesting delayed brain maturation. Longitudinal studies investigating EEG power spectrum maturation in p-FGR infants are lacking, however...

article

Resveratrol mitigates trophoblast and endothelial dysfunction partly via activation of nuclear factor erythroid 2-related factor-2

Seshini Gurusinghe, Annie G. Cox, Rahana Rahman, Siow T. Chan, more

Placenta > 2017 > 60 > C > 74-85

Maternal endothelial dysfunction underlying preeclampsia arises from excessive placental release of anti-angiogenic factors, such as soluble fms-like tyrosine kinase-1 (sFlt1), soluble endoglin (sEng) and activin A. Resveratrol, an activator of the nuclear factor erythroid 2-related factor-2 (Nrf2) transcription factor, mediates the gene expression of antioxidant and vasoprotective factors that may...

article

Customised management of the third stage of labour

Edward Springhall, Euan M. Wallace, Lynne Stewart, Michelle Knight, more

Australian and New Zealand Journal of Obstetrics and Gynaecology > 57 > 3 > 302 - 307

Background Postpartum haemorrhage (PPH) rates are increasing worldwide. The rate is particularly high in women undergoing an induced or augmented labour. In response to this, we altered our hospital's protocol for the management of the third stage of labour to recommend Syntometrine, in preference to oxytocin alone, for women being induced or augmented. We set out to assess the impact of the protocol...

article

Creatine biosynthesis and transport by the term human placenta

Stacey J. Ellery, Paul A. Della Gatta, Clinton R. Bruce, Greg M. Kowalski, more

Placenta > 2017 > 52 > C > 86-93

Creatine is an amino acid derivative that is involved in preserving ATP homeostasis. Previous studies suggest an important role for the creatine kinase circuit for placental ATP turnover. Creatine is obtained from both the diet and endogenous synthesis, usually along the renal-hepatic axis. However, some tissues with a high-energy demand have an inherent capacity to synthesise creatine. In this study,...

article

Human amnion epithelial cells rescue cell death via immunomodulation of microglia in a mouse model of perinatal brain injury

Bryan Leaw, Dandan Zhu, Jean Tan, Ruth Muljadi, more

Stem Cell Research & Therapy > 2017 > 8 > 1 > 1-17

Background Human amnion epithelial cells (hAECs) are clonogenic and have been proposed to reduce inflammatory-induced tissue injury. Perturbation of the immune response is implicated in the pathogenesis of perinatal brain injury; modulating this response could thus be a novel therapy for treating or preventing such injury. The immunomodulatory properties of hAECs have been shown in other animal models,...

article

Maternal Asian ethnicity and obstetric intrapartum intervention: a retrospective cohort study

Maya Reddy, Euan M. Wallace, Joanne C. Mockler, Lynne Stewart, more

BMC Pregnancy and Childbirth > 2017 > 17 > 1 > 1-7

Background Maternal ethnicity is a recognized risk factor for stillbirth, such that South Asian women have higher rates than their Caucasian counterparts. However, whether maternal ethnicity is a risk factor for intrapartum outcomes is less clear. The aim of this study is to explore associations between maternal country of birth, operative vaginal delivery and emergency cesarean section, and to identify...

article

The effects of hydroxychloroquine on endothelial dysfunction

Rahana Rahman, Padma Murthi, Harmeet Singh, Seshini Gurusinghe, more

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2016 > 6 > 4 > 259-262

Hydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of...

article

Obesity and pregnancy outcomes: Do the relationships differ by maternal region of birth? A retrospective cohort study

Miranda Davies-Tuck, Joanne C. Mockler, Lynne Stewart, Michelle Knight, more

BMC Pregnancy and Childbirth > 2016 > 16 > 1 > 1-8

Background We aimed to determine whether the association between obesity and a range of adverse maternal and perinatal outcomes differed in South Asian and Australian and New Zealand born women. Methods A retrospective cohort study of singleton births in South Asian (SA) and Australian/New Zealand (AUS/NZ) born women at an Australian hospital between 2009 and 2013. The interaction between maternal...

article

Antenatal breast milk expression and storage by women with diabetes in pregnancyfor improving infant outcomes

Christine East, Joanne C. Mockler, Willie Dolan, Della Forster

Women and Birth > 2013 > 26 > Supplement 1 > S26

article

An Australian and New Zealand survey of practice of the use of oxytocin at elective caesarean section

Joanne C. MOCKLER, Deirdre J. MURPHY, Euan M. WALLACE

Australian and New Zealand Journal of Obstetrics and Gynaecology > 50 > 1 > 30 - 35

Background: The use of oxytocin to prevent postpartum haemorrhage at elective caesarean section is largely based on evidence derived from vaginal births. Overseas studies indicate wide variation in practice with regard to specific doses of oxytocin administered at caesarean section. No such surveys have been undertaken in Australia or New Zealand. Aims: To survey and report Australian and New Zealand...

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