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The mdx mouse strain is the most widely used experimental model of Duchenne muscular dystrophy (DMD). Although it was previously shown that muscle biopsy specimens obtained from patients with different types of muscular dystrophy contain amyloid, no available publications have analyzed the presence of amyloid aggregates in tissues of DMD patients or mdx mice. The objective of the present work was...
We studied the interrelation between the echocardiographic indices and the indices of collagenolysis system in 68 patients with progressive chronic heart failure with preserved ejection fraction and thick walls of the left ventricle. We found that while the tissue inhibitor TIMP-1 level is independent of the left ventricular dilation status, after being normalized to the individual matrix metalloproteinases...
Currently, there are two points of view on the ability of adult human heart to regenerate. One of them holds that the myocardium has a poor ability to regenerate. According to the other, the myocardium can rapidly regenerate due to the presence of resident stem cells in it. The purpose of this study was to test these hypotheses by investigating the distribution of cardiomyocytes by size and ploidy...
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