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Microtubule associated protein tau is abnormally phosphorylated in Alzheimer's disease (AD) and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs), which are one of the pathological signatures of AD and their presence correlates with severity of dementia. Dysfunction of protein phosphatases in the effected neurons is proposed to be a possible causative factor to AD development...
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