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Ovarian cancer is often diagnosed at advanced stages, when poorly responsive to standard treatment. First-line treatment consists in schemes including cytoreductive surgery followed by adjuvant chemotherapy schemes with platinum and taxane derivatives. Second-line regimens are based on gemcitabine and liposomal doxorubicin. Third line is often not worthwhile because of the high toxicity with poor...
To evaluate the effects of anabolic androgenic steroids (AAS) on chylomicron metabolism.An artificial lipid emulsion labeled with radioactive cholesteryl ester (CE) and triglycerides (TG) mimicking chylomicrons was intravenously injected into individuals who regularly weight trained and made regular use of AAS (WT+AAS group), normolipidemic sedentary individuals (SDT group) and individuals who also...
To evaluate the effects of resistance training (RT) on the metabolism of an LDL-like nanoemulsion and on lipid transfer to HDL, an important step of HDL metabolism.LDL-like nanoemulsion plasma kinetics was studied in 15 healthy men under regular RT for 1–4 years (age=25±5 years, VO 2 peak=50±6mL/kg/min) and in 15 healthy sedentary men (28±7 years, VO 2 peak=35±9mL/kg/min). LDL-like...
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