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Purpose Over expression of ATP-binding cassette transporters is considered one of the major reasons for non-responsiveness to antiepileptic drugs. Carbamazepine (CBZ), one of first line antiepileptic drug is known to influence ABCC2 expression but its exact molecular mechanism is unknown. Methods We investigated the effect of CBZ on expression of ABCC2 and pregnane X receptor (PXR) in HepG2 cell...