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Ibuprofen sodium is the sodium salts form of ibuprofen which exhibits better effects than standard ibuprofen as an analgesic by inhibiting the cyclooxygenase enzyme system. 3-[4-(2-Methylpropyl)phenyl] propanoic acid as one of potential impurities of ibuprofen was determined by a gas chromatography method after the methylation reaction according to the European Pharmacopoeia. Now, a new simple normal...