Search results for: Xing Zhang

Items from 1 to 20 out of 2,109 results

article

Highly Potent and Intestine Specific P‐Glycoprotein Inhibitor to Enable Oral Delivery of Taxol

Xianjing Zhou, Ping Zhang, Yuyan Yang, Wei Shi, more

Angewandte Chemie International Edition > 63 > 45 > n/a - n/a

Taxol is widely used in cancer chemotherapy; however, the oral absorption of Taxol remains a formidable challenge. Since the intestinal p‐glycoprotein (P‐gp) mediated drug efflux is one of the primary causes, the development of P‐gp inhibitor is emerging as a promising strategy to realize Taxol's oral delivery. Because P‐gp exists in many tissues, the non‐selective P‐gp inhibitors would lead to toxicity...

article

Highly Potent and Intestine Specific P‐Glycoprotein Inhibitor to Enable Oral Delivery of Taxol

Xianjing Zhou, Ping Zhang, Yuyan Yang, Wei Shi, more

Angewandte Chemie > 136 > 45 > n/a - n/a

article

Dihydropyridopyrazine Functionalized Xanthene: Generating Stable NIR Dyes with Small‐Molecular Weight by Enhanced Charge Separation

Xing‐Xing Zhang, Feiyu Yang, Xinyu Zhao, Qian Wu, more

Angewandte Chemie > 136 > 42 > n/a - n/a

Near‐infrared region (NIR; 650–1700 nm) dyes offer many advantages over traditional dyes with absorption and emission in the visible region. However, developing new NIR dyes, especially organic dyes with long wavelengths, small molecular weight, and excellent stability and biocompatibility, is still quite challenging. Herein, we present a general method to enhance the absorption and emission wavelengths...

article

Dihydropyridopyrazine Functionalized Xanthene: Generating Stable NIR Dyes with Small‐Molecular Weight by Enhanced Charge Separation

Xing‐Xing Zhang, Feiyu Yang, Xinyu Zhao, Qian Wu, more

Angewandte Chemie International Edition > 63 > 42 > n/a - n/a

article

Cellulosic Nonwovens Incorporated with Fully Utilized MXene Precursor as Smart Pressure Sensor and Multi‐Protection Materials

Zhaochuan Yu, Chao Deng, Jianglei Sun, Xing Zhang, more

Advanced Functional Materials > 34 > 38 > n/a - n/a

Currently, multifunctional MXene‐integrated wearable textiles (MWTs) are particularly appealing due to their various applications such as health monitoring, smart protection, and medical treatment. However, scalable manufacture of durable, stable, and high‐performance multifunctional MWTs still face challenges due to the poor oxidation stability of MXene and low utilization of precursor titanium aluminum...

article

Active Heme Metabolism Suppresses Macrophage Phagocytosis via the TLR4/Type I IFN Signaling/CD36 in Uterine Endometrial Cancer

Xing Zhang, Yi‐Xing Yang, Jia‐Jing Lu, Ding‐Yu Hou, more

American Journal of Reproductive Immunology > 92 > 2 > n/a - n/a

Background Uterine endometrial cancer (UEC) is a common gynecological estrogen‐dependent carcinoma, usually accompanied by intermenstrual bleeding. Active heme metabolism frequently plays an increasingly important role in many diseases, especially in cancers. Tumor‐associated macrophages (TAMs) are the major population in the immune microenvironment of UEC. However, the roles of heme metabolisms...

article

Spatially and Temporally Programmable Transparency Evolutions in Hydrogels Enabled by Metal Coordination toward Transient Anticounterfeiting

Jin Zhao, Yichen Zhou, Xing Zhang, Ying Zheng, more

Small > 20 > 33 > n/a - n/a

Hydrogels have emerged as promising candidates for anticounterfeiting materials, owing to their unique stimulus‐responsive capabilities. To improve the security of encrypted information, efforts are devoted to constructing transient anticounterfeiting hydrogels with a dynamic information display. However, current studies to design such hydrogel materials inevitably include sophisticated chemistry,...

article

6‐3: Development of Internal Compensation Technology for Medium Size OLED Display based on Oxide TFTs

Pan Xu, Ying Han, Hao Zhang, Fengjuan Liu, more

SID Symposium Digest of Technical Papers > 55 > 1 > 37 - 40

To develop the internal compensation for medium size OLED display with high resolution, heavy RC load, and high refresh rate based on oxide TFTs, we employed the pixel of separating compensation and refreshing data, a new PWM‐GOA circuit and a new scan‐GOA circuit. After compensation, the uniformity can be increased from less than 40% to over 80%. We successfully demonstrated 6 inch Panels, which...

article

P‐181: Enhancing the Bragg‐Reflection by Blending Ag Nanoparticles in Polymer Stabilized Cholesteric Liquid Crystals

Yubo Wang, Xing Zhang, Guangjie Lin, Yongfang Zhang, more

SID Symposium Digest of Technical Papers > 55 > 1 > 2072 - 2074

The coupling between the incident light and the highly reflective nanoparticles is believed to potentially raise the reflective intensity of PSCLCs by creating a channel that causes the incident light to reach the helical CLCs and reflect outward. Therefore, in this research Ag nanoparticles were blended into polymer stabilized cholesteric liquid crystals (PSCLCs) to enhance their reflective intensity...

article

P‐190: Photo‐triggered Transmission‐color Through a Cholesteric Liquid Crystal for Multi‐level Information Encryption

Yongguang Chen, Guangjie Lin, Xing Zhang, Xiaohui Gong, more

SID Symposium Digest of Technical Papers > 55 > 1 > 2112 - 2114

In this research, the house‐made transparent cell with a cell gap of 10 μm was made using one glass slide that coated with commercial polyimide and the other one coated by SD1 photo‐responsive molecules, and filled with CLCs made from E7 nematic LCs and 1.0% S811 doping in the pitch of 10 μm. The LCs on SD1 molecules coated slide thereafter were in‐plane switched clock‐wisely by means of linear polarized...

article

P‐1.12: Sub‐200nm Nano‐scale Indium‐Zinc‐Oxide Ultra‐thin Channel Transistors

Minghe Zhang, Dengqin Xu, Ruibin Duan, Jianbing Shi, more

SID Symposium Digest of Technical Papers > 55 > S1 > 664 - 666

Herein, nanoscale Indium‐Zinc‐Oxide (IZO) transistors are fabricated successfully in 5 nm channel thickness and 182.3 nm length, exhibiting excellent electrical properties including a high on‐state current (I_on) of 137 μA/μm, subthreshold swing (SS) of 70.87 mV/dec., turn‐on voltage (V_on) of ‐0.12 V, low drain induced barrier lowering of 22.7 mV/V and preferable hysteresis. Our findings promote application...

article

P‐1.15: Improving the Performance of IZO Transistor by Adding Buffer Layer

Longhai Xiong, Jianbing Shi, Jingye xie, Junchen Dong, more

SID Symposium Digest of Technical Papers > 55 > S1 > 673 - 675

In this work, we studied the effect of the different thickness buffer layer on the electrical characteristics of InZnO (IZO) transistors. We found that when a 20nm layer of indium‐aluminum‐zinc oxide (IAZO) was added as the buffer layer between S/D electrodes and the active layer, the IZO transistor exhibited optimum electrical performance, with a high on/off drain current ratio of 2.61 ×10⁷, the...

article

P‐1.11: Back‐End‐of‐Line Compatible Al‐doped Indium Zinc Oxide Transistors with Excellent Thermal Stability

Jingye Xie, Jianbing Shi, Junchen Dong, Zongwei Wang, more

SID Symposium Digest of Technical Papers > 55 > S1 > 661 - 663

In this work, thermal stability of InZnO (IZO) and Al‐doped InZnO (IAZO) transistors are studied. With a consecutive annealing pre‐treatment at 300 ℃ in air, the IAZO transistors show superior electrical properties to the IZO transistors, demonstrating that element Al plays a role as stabilizer for maintaining device performance. Our work paves the way for practical application of the oxide transistors...

article

P‐1.14: Effects of Active Layer Thickness on Performance of InZnO Transistors

Jianbing Shi, Qi Li, Jingye Xie, Longhai Xiong, more

SID Symposium Digest of Technical Papers > 55 > S1 > 670 - 672

Oxide transistors attract much attention in fields of displays and low‐cost integrated circuits (ICs). In the present work, IZO transistors were fabricated and the effects of active layer thickness on electrical characteristics of IZO transistors were studied. The devices with IZO thickness of 10 nm show the best electrical characteristics with a high on/off current ratio of 3.4×10 ⁸ , a large field‐effect...

article

Effect of enzymatic hydrolysis of arabinoxylan on the quality of frozen dough during the subfreezing process

Nannan Zhu, Yufen Liu, Xing Zhang, Haiyan Gao, more

Journal of the Science of Food and Agriculture > 104 > 10 > 6062 - 6069

BACKGROUND The objective of this investigation was to examine the impact of enzymatic hydrolysis of arabinoxylan (AX) on frozen dough quality under subfreezing conditions. The dough was subjected to freezing at −40 °C for 2 h and then stored at −9, −12, and −18 °C for 15 days. The water loss, freezable water content, water migration, and microstructure of the dough were measured. RESULTS The dough...

article

Study on the stability of molecular chirality and the configuration protection of dihydromyricetin in vine tea

Shuang Li, Xuming Sha, Shanshan Sun, Xing Zhang, more

Journal of Food Science > 89 > 6 > 3569 - 3576

This study aims to investigate the impact of four key factors, namely, temperature, water source, metal ion, and pH, on the stability of molecular chirality of dihydromyricetin (DMY) and proposed effective strategies for configuration protection. The findings reveal that temperatures exceeding 80°C could accelerate the racemization process of DMY, with a significant increase in racemization observed...

article

Heme metabolism and HO‐1 in the pathogenesis and potential intervention of endometriosis

Ding‐Yu Hou, Jia‐Jing Lu, Xing Zhang, Ayitila Abudukeyoumu, more

American Journal of Reproductive Immunology > 91 > 5 > n/a - n/a

Endometriosis (EM) is one of the diseases related to retrograded menstruation and hemoglobin. Heme, released from hemoglobin, is degraded by heme oxygenase‐1 (HO‐1). In EM lesions, heme metabolites regulate processes such as inflammation, redox balance, autophagy, dysmenorrhea, malignancy, and invasion, where macrophages (Mø) play a fundamental role in their interactions. Regulation occurs at molecular,...

article

The inflammatory‐nutritional score and nomogram for R0 resected head and neck soft tissue sarcoma

Bushu Xu, Haibo Qiu, Biyi Ou, Shuwei Chen, more

Oral Diseases > 30 > 3 > 1139 - 1151

Objectives To explore the predictive value of inflammatory‐nutritional score (INS) and a nomogram for survivals in head and neck soft tissue sarcoma (HNSTS) patients with negative resection margins (R0). Methods Clinical characteristics and hematological features of 315 HNSTS patients underwent R0 surgery were analyzed. Results The 5‐year overall survival (OS) rate, 3‐year recurrence‐free survival...

article

Adult epithelioid glioblastoma exhibits an extremely poor prognosis and high frequency of SWI/SNF complex mutation: Insights from a retrospective study

Shaoyan Xi, Shimeng Jiang, Hainan Li, Qitao Huang, more

International Journal of Cancer > 155 > 1 > 172 - 183

Epithelioid glioblastoma (eGBM) is a rare subtype of GBM. Given the update of the definition of GBM, the understanding of the molecular characteristics and prognosis of “true” adult eGBM remains limited. Herein, we retrospectively analyzed the clinicopathological data of 39 adult eGBM cases. Adult eGBM primarily affected females, with a male‐to‐female ratio of 1:2.3. The average age of diagnosis was...

article

PHGDH knockdown increases sensitivity to SR1, an aryl hydrocarbon receptor antagonist, in colorectal cancer by activating the autophagy pathway

Hong‐Ming Li, Xiang Li, Ran Xia, Xing Zhang, more

The FEBS Journal > 291 > 8 > 1780 - 1794

Colorectal cancer (CRC) has emerged as the third most prevalent and second deadliest cancer worldwide. Metabolic reprogramming is a key hallmark of cancer cells. Phosphoglycerate dehydrogenase (PHGDH) is over‐expressed in multiple cancers, including CRC. Although the role of PHGDH in metabolism has been extensively investigated, its effects on CRC development remains to be elucidated. In the present...

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INFONA - science communication portal

Search results for: Xing Zhang

Highly Potent and Intestine Specific P‐Glycoprotein Inhibitor to Enable Oral Delivery of Taxol

Highly Potent and Intestine Specific P‐Glycoprotein Inhibitor to Enable Oral Delivery of Taxol

Dihydropyridopyrazine Functionalized Xanthene: Generating Stable NIR Dyes with Small‐Molecular Weight by Enhanced Charge Separation

Dihydropyridopyrazine Functionalized Xanthene: Generating Stable NIR Dyes with Small‐Molecular Weight by Enhanced Charge Separation

Cellulosic Nonwovens Incorporated with Fully Utilized MXene Precursor as Smart Pressure Sensor and Multi‐Protection Materials

Active Heme Metabolism Suppresses Macrophage Phagocytosis via the TLR4/Type I IFN Signaling/CD36 in Uterine Endometrial Cancer

Spatially and Temporally Programmable Transparency Evolutions in Hydrogels Enabled by Metal Coordination toward Transient Anticounterfeiting

6‐3: Development of Internal Compensation Technology for Medium Size OLED Display based on Oxide TFTs

P‐181: Enhancing the Bragg‐Reflection by Blending Ag Nanoparticles in Polymer Stabilized Cholesteric Liquid Crystals

P‐190: Photo‐triggered Transmission‐color Through a Cholesteric Liquid Crystal for Multi‐level Information Encryption

P‐1.12: Sub‐200nm Nano‐scale Indium‐Zinc‐Oxide Ultra‐thin Channel Transistors

P‐1.15: Improving the Performance of IZO Transistor by Adding Buffer Layer

P‐1.11: Back‐End‐of‐Line Compatible Al‐doped Indium Zinc Oxide Transistors with Excellent Thermal Stability

P‐1.14: Effects of Active Layer Thickness on Performance of InZnO Transistors

Effect of enzymatic hydrolysis of arabinoxylan on the quality of frozen dough during the subfreezing process

Study on the stability of molecular chirality and the configuration protection of dihydromyricetin in vine tea

Heme metabolism and HO‐1 in the pathogenesis and potential intervention of endometriosis

The inflammatory‐nutritional score and nomogram for R0 resected head and neck soft tissue sarcoma

Adult epithelioid glioblastoma exhibits an extremely poor prognosis and high frequency of SWI/SNF complex mutation: Insights from a retrospective study

PHGDH knockdown increases sensitivity to SR1, an aryl hydrocarbon receptor antagonist, in colorectal cancer by activating the autophagy pathway

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