Search results for: Doralina L. Anghelescu

Items from 1 to 20 out of 34 results

article

Anesthesia and epidural analgesia for “heroic” cancer surgery

Doralina L. Anghelescu, Charles B. Berde

Pediatric Anesthesia > 33 > 3 > 182 - 184

article

A retrospective investigation of the relationship between neuroblastoma response to anti‐GD2 monoclonal antibodies and exposure to opioids for pain management

Kyle J. Morgan, Andrew Dudas, Wayne L. Furman, M. Beth McCarville, more

Pediatric Blood & Cancer > 70 > 2 > n/a - n/a

Objective Recent increased awareness and research studies reflect possible associations between opioid exposure and cancer outcomes. Children with neuroblastoma (NB) often require opioid treatment for pain. However, associations between tumor response to chemotherapy and opioid exposure have not been investigated in clinical settings. Methods This is a single‐institution retrospective review of...

article

Low‐dose ketamine infusions reduce opioid use in pediatric and young adult oncology patients

Doralina L Anghelescu, Stephanie Ryan, Diana Wu, Kyle J. Morgan, more

Pediatric Blood & Cancer > 69 > 9 > n/a - n/a

Background Ketamine is an NMDA‐receptor antagonist with analgesic and opioid‐sparing properties. Although well studied in adults, more robust evidence supporting ketamine's use for pediatric pain management is needed. This retrospective study evaluates ketamine's opioid‐sparing effectiveness in pediatric and young adult oncology and hematology patients. Procedure Continuous ketamine infusions administered...

article

Lidocaine infusions and reduced opioid consumption—Retrospective experience in pediatric hematology and oncology patients with refractory pain

Doralina L. Anghelescu, Kyle J. Morgan, Michael J. Frett, Diana Wu, more

Pediatric Blood & Cancer > 68 > 11 > n/a - n/a

Background Despite a more robust experience with lidocaine infusions for pain management in adults and general pediatric population, there is limited evidence of efficacy of lidocaine infusions for pain management in patients with pediatric hematology and oncology diagnoses. Methods Data pertaining to continuous intravenous lidocaine infusions prescribed between January 2009 and June 2019 were...

article

Pain and functional outcomes in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort study

Ingrid Tonning Olsson, Nicole M. Alberts, Chenghong Li, Matthew J. Ehrhardt, more

Cancer > 127 > 10 > 1679 - 1689

Background Although survivors of childhood cancer are at risk of chronic pain, the impact of pain on daily functioning is not well understood. Methods A total of 2836 survivors (mean age, 32.2 years [SD, 8.5 years]; mean time since diagnosis, 23.7 years [SD, 8.2 years]) and 343 noncancer community controls (mean age, 35.5 years [SD, 10.2 years]) underwent comprehensive medical, neurocognitive,...

article

Prospective randomized trial of interventions for vincristine‐related neuropathic pain

Doralina L. Anghelescu, Jessica Michala Tesney, Sima Jeha, Becky B. Wright, more

Pediatric Blood & Cancer > 67 > 9 > n/a - n/a

Background To evaluate the efficacy of gabapentin at 20 mg/kg per day in the treatment of vincristine‐related neuropathic pain. Procedure Children aged 1‐18 years who developed vincristine‐induced neuropathy on a St Jude frontline acute lymphoblastic leukemia trial were prospectively enrolled on a randomized, double‐blind, placebo‐controlled, phase II trial with two treatment arms: gabapentin plus...

article

Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline

Erik A.H. Loeffen, Leontien C.M. Kremer, Marianne D. de Wetering, Renée L. Mulder, more

Pediatric Blood & Cancer > 66 > 6 > n/a - n/a

Although pain is one of the most prevalent and bothersome symptoms children with cancer experience, evidence‐based guidance regarding assessment and management is lacking. With 44 international, multidisciplinary healthcare professionals and nine patient representatives, we aimed to develop a clinical practice guideline (following GRADE methodology), addressing assessment and pharmacological, psychological,...

article

Neuropathic Pain in Pediatric Oncology: A Clinical Decision Algorithm

Doralina L. Anghelescu, Jessica Michala Tesney

Pediatric Drugs > 2019 > 21 > 2 > 59-70

Neuropathic pain in pediatric oncology can be caused by distinct lesions or disease processes affecting the somatosensory system, including chemotherapy-related neuronal injury, solid tumor-related involvement of neural structures, post-surgical neuropathic pain—including phantom limb pain and pain after limb-sparing surgery—and the complex circumstances of neuropathic pain at the end of life. Treatment...

article

Anesthesia and Pain Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Desmoplastic Small Round Cell Tumors in Children, Adolescents, and Young Adults

Doralina L. Anghelescu, Christina-Lin Brown, Andrew J. Murphy, Andrew M. Davidoff, more

Annals of Surgical Oncology > 2019 > 26 > 1 > 131-138

Background Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may improve survival. Methods A retrospective review of anesthetic management and postoperative pain control strategies after CRS/HIPEC for DSRCT from 2013 to 2017 was performed. Results The review analyzed 10 CRS/HIPEC procedures...

article

Methadone for Pain Management in Children with Cancer

Catherine Habashy, Erin Springer, Elizabeth A. Hall, Doralina L. Anghelescu

Pediatric Drugs > 2018 > 20 > 5 > 409-416

Methadone is a synthetic opioid with unique pharmacodynamic and pharmacokinetic properties. It is effective in treating both nociceptive and neuropathic pain, which commonly co-exist in children with cancer. Upon reviewing the literature describing the use of methadone in pediatric oncology patients, publications are limited in number and low in quality of evidence; nevertheless, there is support...

article

Parent perspectives and preferences for strategies regarding nonsedated MRI scans in a pediatric oncology population

Breya Walker, Heather M. Conklin, Doralina L. Anghelescu, Lacey P. Hall, more

Supportive Care in Cancer > 2018 > 26 > 6 > 1815-1824

Purpose Children with cancer frequently require MRI scans for clinical purposes. Sedation with general anesthesia (GA) is often used to promote compliance, reduce motion, and alleviate anxiety. The use of GA for MRI scans is costly in terms of time, personnel, and medications. In addition, prominent risks are associated with anesthesia exposure in patients with complex medical conditions. Successful...

article

State of the Art Management of Acute Vaso-occlusive Pain in Sickle Cell Disease

Latika Puri, Kerri A. Nottage, Jane S. Hankins, Doralina L. Anghelescu

Pediatric Drugs > 2018 > 20 > 1 > 29-42

Acute vaso-occlusive crisis (VOC) is a hallmark of sickle cell disease (SCD). Multiple complex pathophysiological processes can result in pain during a VOC. Despite significant improvements in the understanding and management of SCD, little progress has been made in the management of pain in SCD, although new treatments are being explored. Opioids and non-steroidal anti-inflammatory drugs (NSAIDs)...

article

Erratum to: Emergence Delirium in Pediatric Anesthesia

Arthura D. Moore, Doralina L. Anghelescu

Pediatric Drugs > 2017 > 19 > 3 > 267-267

The online version of the original article can be found under doi: 10.1007/s40272-016-0201-5 .

article

The role of the pediatric anesthesiologist in relieving suffering at the end of life: when is palliative sedation appropriate in pediatrics?

Doralina L. Anghelescu, Esther Knapp, Liza‐Marie Johnson, Justin N. Baker

Pediatric Anesthesia > 27 > 4 > 443 - 444

article

Prospective study of neuropathic pain after definitive surgery for extremity osteosarcoma in a pediatric population

Doralina L. Anghelescu, Brenda D. Steen, Huiyun Wu, Jianrong Wu, more

Pediatric Blood & Cancer > 64 > 3 > n/a - n/a

Background Neuropathic pain (NP) after definitive surgery for extremity osteosarcoma (OS) has not been previously characterized. This study prospectively investigates the incidence, duration, and treatment of NP in limb sparing surgery and amputation groups. Procedure In patients treated for OS on a chemotherapy and definitive surgery (limb sparing vs. amputation) protocol (OS08), we prospectively...

article

Emergence Delirium in Pediatric Anesthesia

Arthura D. Moore, Doralina L. Anghelescu

Pediatric Drugs > 2017 > 19 > 1 > 11-20

Emergence delirium (ED) is a complex of perceptual disturbances and psychomotor agitation that occurs most commonly in preschool-aged children in the early postanesthetic period. The incidence of ED varies between 10 and 80% in children and is perceived as a troublesome clinical situation by 42% of pediatric anesthesiologists. Although these events are often short lived, they increase the risk of...

article

Pediatric Oncology: Managing Pain at the End of Life

Jennifer M. Snaman, Justin N. Baker, Jennifer H. Ehrentraut, Doralina L. Anghelescu

Pediatric Drugs > 2016 > 18 > 3 > 161-180

Pain is a common and highly distressing symptom in pediatric patients with advanced malignancies. Prompt recognition, assessment, and treatment of pain are necessary, especially at the end of life. Opioid medications remain the mainstay of treatment of malignant pain in children at the end of life and the amount of opioids required for adequate pain control in patients is highly variable. Nonpharmacological...

article

Patterns of End-of-Life Care in Children With Advanced Solid Tumor Malignancies Enrolled on a Palliative Care Service

Tamara Z. Vern-Gross, Catherine G. Lam, Zachary Graff, Sara Singhal, more

Journal of Pain and Symptom Management > 2015 > 50 > 3 > 305-312

Pediatric patients with solid tumors can have a significant symptom burden that impacts quality of life (QoL) and end-of-life care needs.We evaluated outcomes and symptoms in children with solid tumors and compared patterns of end-of-life care after implementation of a dedicated institutional pediatric palliative care (PC) service.We performed a retrospective cohort study of children with solid tumors...

article

Patient‐controlled analgesia at the end of life at a pediatric oncology institution

Doralina L. Anghelescu, Jennifer M. Snaman, Luis Trujillo, April D. Sykes, more

Pediatric Blood & Cancer > 62 > 7 > 1237 - 1244

BackgroundPatient controlled anesthesia (PCA) is increasingly used to manage pain in pediatric cancer patients and is important in the treatment of escalating pain at the end of life. The description of the use of opioid PCA in this population has been limited. ProcedureThis retrospective chart review of the last 2 weeks of life addressed the following objectives: (1) to describe the patient population...

article

Comparison of pain outcomes between two anti‐GD2 antibodies in patients with neuroblastoma

Doralina L. Anghelescu, Jacob L. Goldberg, Lane G. Faughnan, Jianrong Wu, more

Pediatric Blood & Cancer > 62 > 2 > 224 - 228

Background Addition of anti‐GD2 antibody ch14.18 to the treatment of neuroblastoma has improved outcomes. The most common side effect of ch14.18 is neuropathic pain, which may in part be complement‐mediated. Hu14.18K322A is a humanized anti‐GD2 antibody designed to diminish complement activation and induce less pain. We compare the pain outcomes in patients treated with ch14.18 and those treated...

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INFONA - science communication portal

Search results for: Doralina L. Anghelescu

Anesthesia and epidural analgesia for “heroic” cancer surgery

A retrospective investigation of the relationship between neuroblastoma response to anti‐GD2 monoclonal antibodies and exposure to opioids for pain management

Low‐dose ketamine infusions reduce opioid use in pediatric and young adult oncology patients

Lidocaine infusions and reduced opioid consumption—Retrospective experience in pediatric hematology and oncology patients with refractory pain

Pain and functional outcomes in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort study

Prospective randomized trial of interventions for vincristine‐related neuropathic pain

Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline

Neuropathic Pain in Pediatric Oncology: A Clinical Decision Algorithm

Anesthesia and Pain Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Desmoplastic Small Round Cell Tumors in Children, Adolescents, and Young Adults

Methadone for Pain Management in Children with Cancer

Parent perspectives and preferences for strategies regarding nonsedated MRI scans in a pediatric oncology population

State of the Art Management of Acute Vaso-occlusive Pain in Sickle Cell Disease

Erratum to: Emergence Delirium in Pediatric Anesthesia

The role of the pediatric anesthesiologist in relieving suffering at the end of life: when is palliative sedation appropriate in pediatrics?

Prospective study of neuropathic pain after definitive surgery for extremity osteosarcoma in a pediatric population

Emergence Delirium in Pediatric Anesthesia

Pediatric Oncology: Managing Pain at the End of Life

Patterns of End-of-Life Care in Children With Advanced Solid Tumor Malignancies Enrolled on a Palliative Care Service

Patient‐controlled analgesia at the end of life at a pediatric oncology institution

Comparison of pain outcomes between two anti‐GD2 antibodies in patients with neuroblastoma

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