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Background Cisplatin-based chemotherapy is highly effective in metastasized germ cell tumours (GCT). However, 10–30 % of patients develop resistance to cisplatin, requiring salvage therapy. We investigated the in vitro activity of paclitaxel and the novel taxane cabazitaxel in cisplatin-sensitive and -resistant GCT cell lines. Methods In vitro activity of paclitaxel and cabazitaxel was determined...
Four isoforms of actinoporins were isolated in 2002–2004 from the tropical sea anemone Heteractis crispa (=Radianthus macrodactylus). Their potent hemolytic activities and effects on Ehrlich ascites carcinoma bearing mice were also studied. In this study, the individual actinoporin (RTX-A) demonstrated potential cancer-preventive activity at extremely low and non-cytotoxic concentrations. The substance...
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