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Rationale Several lines of recent evidence suggest that endocannabinoids affect behavior by influencing the general patterns of challenge responding. Objectives Here, we investigated the brain mechanisms underlying this phenomenon in rats. Methods The anandamide hydrolysis inhibitor URB597 was condensed into the tip of stainless steel cannulae, which were chronically implanted slightly above the...
The gene(s) encoding for endomorphin precursor(s) is/are still unknown. We have raised the possibility of and did find some evidence for a potential de novo biosynthetic route starting from Tyr-Pro precursor. To pursue further this possibility we measured the generation of immunoreactive endomorphin-2 (E2-IR) in adult rat isolated L4,5 dorsal root ganglia.In rat isolated dorsal root ganglia the combination...
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