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Purpose To analyze clinical results and quality of life of patients with localized prostate cancer after irradiation of the prostate with an 18F-choline-PET/CT-based simultaneous integrated boost (SIB) in comparison to a control group without SIB. Methods A total of 134 patients underwent intensity-modulated radiotherapy from 2007–2010. All patients received a total dose of 76 Gy with 2 Gy fractions...