Search results for: Reina Bendayan

Items from 1 to 20 out of 36 results

article

The journey to AAPS 2020: a reflection from strategic planning to PharmSci 360

Joseph W. Polli, Christopher R. McCurdy, Dale Eric Wurster, Binodh S. DeSilva, more

AAPS Open > 2018 > 4 > 1 > 1-4

Statement of Copublication This article was simultaneously published in AAPS Open, The AAPS Journal, and AAPS PharmSciTech. https://doi.org/10.1186/s41120-018-0028-y, https://doi.org/10.1208/s12248-018-0273-y or https://doi.org/10.1208/s12249-018-1200-3. The American Association of Pharmaceutical Scientists (AAPS) holds copyright for this article.

article

The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360

Joseph W. Polli, Christopher R. McCurdy, Dale Eric Wurster, Binodh S. DeSilva, more

The AAPS Journal > 2019 > 21 > 1 > 1-3

article

The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360

Joseph W. Polli, Christopher R. McCurdy, Dale Eric Wurster, Binodh S. DeSilva, more

AAPS PharmSciTech > 2018 > 19 > 8 > 3325-3327

article

Two‐Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2‐Positive Breast Cancer

Chunsheng He, Jason Li, Ping Cai, Taksim Ahmed, more

Advanced Functional Materials > 28 > 9 > n/a - n/a

Therapeutic antibodies (e.g., trastuzumab, TRA) against human epidermal growth factor receptor 2 (HER2)‐positive breast cancers have shown benefits in controlling primary tumors, yet are ineffective against brain metastases due to their inability to cross the blood‐brain barrier (BBB). A novel hybrid nanoconstruct system is designed to deliver trastuzumab to brain metastasis of HER2‐positive breast...

article

Aryl hydrocarbon receptor upregulates IL-1β expression in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure

Aude Jacob, Céline Tomkiewicz-Raulet, Charlotte Jamet, Reina Bendayan, more

Toxicology in Vitro > 2017 > 41 > C > 200-204

The AhR is a cytosolic ligand-dependent transcription factor activated by both endogenous and exogenous chemicals. It can regulate expression of many target genes including some inflammatory cytokines and chemokines. To date AhR implication in the regulation of inflammatory cytokines and chemokines at human cerebral endothelium has not been addressed. In the present study, we investigated whether...

article

Peroxisome proliferator-activated receptor-gamma: potential molecular therapeutic target for HIV-1-associated brain inflammation

Amila Omeragic, Md Tozammel Hoque, U-yeong Choi, Reina Bendayan

Journal of Neuroinflammation > 2017 > 14 > 1 > 1-13

Background Despite the use of combination antiretroviral therapy for the treatment of HIV-1 infection, cognitive impairments remain prevalent due to persistent viral replication and associated brain inflammation. Primary cellular targets of HIV-1 in the brain are macrophages, microglia, and to a certain extent astrocytes which in response to infection release inflammatory markers, viral proteins [i...

article

Role and modulation of drug transporters in HIV-1 therapy

Camille Alam, Sana-Kay Whyte-Allman, Amila Omeragic, Reina Bendayan

Advanced Drug Delivery Reviews > 2016 > 103 > C > 121-143

Current treatment of human immunodeficiency virus type-1 (HIV-1) infection involves a combination of antiretroviral drugs (ARVs) that target different stages of the HIV-1 life cycle. This strategy is commonly referred to as highly active antiretroviral therapy (HAART) or combined antiretroviral therapy (cART). Membrane-associated drug transporters expressed ubiquitously in mammalian systems play a...

chapter

Multidrug Resistance in Solid Tumor and Its Reversal

Ho Lun Wong, Xiao Yu Wu, Reina Bendayan

Pharmaceutical Perspectives of Cancer Therapeutics > 121-148

Chemotherapy was first used for the treatment of advanced lymphomas in the 1940s [1]. Since then several classes of chemotherapeutic compounds such as alkylating agents, antimetabolites, anthracyclines, plant alkaloids, and later topoisomerase inhibitors and taxanes have been identified or synthesized to treat various forms of cancer [2, 3]. Although numerous in vitro and animal studies have demonstrated...

article

In vivo and ex vivo regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator‐activated receptor alpha (Pparα) at the blood–brain barrier

Md. Tozammel Hoque, Arpit Shah, Vijay More, David S. Miller, more

Journal of Neurochemistry > 135 > 6 > 1113 - 1122

Breast cancer resistance protein (Bcrp/Abcg2) localized at the blood–brain barrier (BBB) limits permeability into the brain of many xenobiotics, including pharmacological agents. Peroxisome proliferator‐activated receptor α (Pparα), a ligand‐activated transcription factor, primarily involved in lipid metabolism, has been shown to regulate the functional expression of Bcrp in human cerebral microvascular...

article

125I-Labelled 2-Iodoestrone-3-sulfate: synthesis, characterization and OATP mediated transport studies in hormone dependent and independent breast cancer cells

Nilasha Banerjee, T. Robert Wu, Jason Chio, Ryan Kelly, more

Nuclear Medicine and Biology > 2015 > 42 > 3 > 274-282

Organic Anion Transporting Polypeptides (OATP) are a family of membrane associated transporters that facilitate estrone-3-sulphate (E3S) uptake by hormone dependent, post-menopausal breast cancers. We have established E3S as a potential ligand for targeting hormone dependent breast cancer cells, and in this study sought to prepare and investigate radioiodinated E3S as a tool to study the OATP system...

article

Expression of ATP-binding cassette membrane transporters in a HIV-1 transgenic rat model

Kevin R. Robillard, Md Tozammel Hoque, Reina Bendayan

Biochemical and Biophysical Research Communications > 2014 > 444 > 4 > 531-536

P-glycoprotein (P-gp, product of Mdr1a and Mdr1b genes), multidrug resistance associated proteins (Mrps), and breast cancer resistance protein (Bcrp), all members of the ATP-binding cassette (ABC) membrane-associated drug transporters superfamily, can significantly restrict the entry of antiretroviral drugs (ARVs) into organs which exhibit a barrier function such as the central nervous system (CNS)...

article

In Vitro and In Situ Evaluation of pH-Dependence of Atazanavir Intestinal Permeability and Interactions with Acid-Reducing Agents

Olena Kis, Sharon L. Walmsley, Reina Bendayan

Pharmaceutical Research > 2014 > 31 > 9 > 2404-2419

Purpose The objectives of this study were to evaluate the effects of intestinal lumen pH, food intake, and acid-reducing agents on the intestinal permeability of atazanavir, an HIV-1 protease inhibitor. Methods Atazanavir permeability across Caco-2 cell monolayers (P _app) and in situ steady-state permeability across rat jejunum and ileum (P _eff) were evaluated in buffers of varied pH (4.5–8.5),...

article

Expression of membrane transporters and metabolic enzymes involved in estrone-3-sulphate disposition in human breast tumour tissues

Nilasha Banerjee, Naomi Miller, Christine Allen, Reina Bendayan

Breast Cancer Research and Treatment > 2014 > 145 > 3 > 647-661

Two-thirds of newly diagnosed hormone-dependent (HR+) breast cancers are detected in post-menopausal patients where estrone-3-sulphate (E3S) is the predominant source for tumour estradiol. Understanding intra-tumoral fate of E3S would facilitate in the identification of novel molecular targets for HR + post-menopausal breast cancer patients. Hence this study investigates the clinical expression of...

article

In vivo induction of P‐glycoprotein expression at the mouse blood–brain barrier: an intracerebral microdialysis study

Gary N. Y. Chan, Victor Saldivia, Yingbo Yang, Henrianna Pang, more

Journal of Neurochemistry > 127 > 3 > 342 - 352

Intracerebral microdialysis was utilized to investigate the effect of P‐glycoprotein (a drug efflux transporter) induction at the mouse blood–brain barrier (BBB) on brain extracellular fluid concentrations of quinidine, an established substrate of P‐glycoprotein. Induction was achieved by treating male CD‐1 mice for 3 days with 5 mg/kg/day dexamethasone (DEX), a ligand of the nuclear receptor, pregnane...

article

Role of nuclear receptors in the regulation of drug transporters in the brain

Gary N.Y. Chan, Md. Tozammel Hoque, Reina Bendayan

Trends in Pharmacological Sciences > 2013 > 34 > 7 > 361-372

ATP-binding cassette membrane-associated drug efflux transporters and solute carrier influx transporters, expressed at the blood–brain barrier, blood–cerebrospinal fluid barrier, and in brain parenchyma, are important determinants of drug disposition in the central nervous system. Targeting the regulatory pathways that govern the expression of these transporters could provide novel approaches to selectively...

article

Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment

Shannon Dallas, Michelle L Block, Deborah M Thompson, Marcelo G Bonini, more

Journal of Neuroinflammation > 2013 > 10 > 1 > 1-14

Background Active HIV infection within the central nervous system (CNS) is confined primarily to microglia. The glial cell compartment acts as a viral reservoir behind the blood-brain barrier. It provides an additional roadblock to effective pharmacological treatment via expression of multiple drug efflux transporters, including P-glycoprotein. HIV/AIDS patients frequently suffer bacterial and viral...

article

Role of Drug Efflux and Uptake Transporters in Atazanavir Intestinal Permeability and Drug-Drug Interactions

Olena Kis, Jason A. Zastre, Md. Tozammel Hoque, Sharon L. Walmsley, more

Pharmaceutical Research > 2013 > 30 > 4 > 1050-1064

Purpose To investigate the role of membrane-associated drug transporters in regulating the intestinal absorption of the HIV-1 protease inhibitor, atazanavir, and assess the potential contribution of these transporters in clinical interactions of atazanavir with other protease inhibitors and tenofovir disoproxil fumarate (TDF). Methods Intestinal permeability of atazanavir was investigated in vitro...

article

1α,25‐Dihydroxyvitamin D₃‐liganded vitamin D receptor increases expression and transport activity of P‐glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells

Matthew R. Durk, Gary N.Y. Chan, Christopher R. Campos, John C. Peart, more

Journal of Neurochemistry > 123 > 6 > 944 - 953

Induction of the multidrug resistance protein 1 (MDR1)/P‐glycoprotein (P‐gp) by the vitamin D receptor (VDR) was investigated in isolated rat brain capillaries and rat (RBE4) and human (hCMEC/D3) brain microvessel endothelial cell lines. Incubation of isolated rat brain capillaries with 10 nM of the VDR ligand, 1α,25‐dihydroxyvitamin D₃ [1,25(OH)₂D₃] for 4 h increased P‐gp protein expression fourfold...

article

Nanotechnological advances for the delivery of CNS therapeutics

Ho Lun Wong, Xiao Yu Wu, Reina Bendayan

Advanced Drug Delivery Reviews > 2012 > 64 > 7 > 686-700

Effective non-invasive treatment of neurological diseases is often limited by the poor access of therapeutic agents into the central nervous system (CNS). The majority of drugs and biotechnological agents do not readily permeate into brain parenchyma due to the presence of two anatomical and biochemical dynamic barriers: the blood–brain barrier (BBB) and blood–cerebrospinal fluid barrier (BCSFB)....

article

Regulation of P‐glycoprotein by human immunodeficiency virus‐1 in primary cultures of human fetal astrocytes

Tamima Ashraf, Patrick T. Ronaldson, Yuri Persidsky, Reina Bendayan

Journal of Neuroscience Research > 89 > 11 > 1773 - 1782

P‐glycoprotein (P‐gp), a drug efflux pump, is known to alter the bioavailability of antiretroviral drugs at several sites, including the brain. We have previously shown that human immunodeficiency virus‐1 (HIV‐1) glycoprotein 120 (gp120) induces proinflammatory cytokine secretion and decreases P‐gp functional expression in rat astrocytes, a cellular reservoir of HIV‐1. However, whether P‐gp is regulated...

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INFONA - science communication portal

Search results for: Reina Bendayan

The journey to AAPS 2020: a reflection from strategic planning to PharmSci 360

The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360

The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360

Two‐Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2‐Positive Breast Cancer

Aryl hydrocarbon receptor upregulates IL-1β expression in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure

Peroxisome proliferator-activated receptor-gamma: potential molecular therapeutic target for HIV-1-associated brain inflammation

Role and modulation of drug transporters in HIV-1 therapy

Multidrug Resistance in Solid Tumor and Its Reversal

In vivo and ex vivo regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator‐activated receptor alpha (Pparα) at the blood–brain barrier

125I-Labelled 2-Iodoestrone-3-sulfate: synthesis, characterization and OATP mediated transport studies in hormone dependent and independent breast cancer cells

Expression of ATP-binding cassette membrane transporters in a HIV-1 transgenic rat model

In Vitro and In Situ Evaluation of pH-Dependence of Atazanavir Intestinal Permeability and Interactions with Acid-Reducing Agents

Expression of membrane transporters and metabolic enzymes involved in estrone-3-sulphate disposition in human breast tumour tissues

In vivo induction of P‐glycoprotein expression at the mouse blood–brain barrier: an intracerebral microdialysis study

Role of nuclear receptors in the regulation of drug transporters in the brain

Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment

Role of Drug Efflux and Uptake Transporters in Atazanavir Intestinal Permeability and Drug-Drug Interactions

1α,25‐Dihydroxyvitamin D₃‐liganded vitamin D receptor increases expression and transport activity of P‐glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells

Nanotechnological advances for the delivery of CNS therapeutics

Regulation of P‐glycoprotein by human immunodeficiency virus‐1 in primary cultures of human fetal astrocytes

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