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Background This study assesses the chemotherapeutic drug gemcitabine in the human non-small cell lung cancer (NSCLC) cell line KNS62 in relation to the CD95-induced apoptotic pathway, and the role of the anti-apoptotic protein Bcl-xL in vitro and in vivo. Materials and methods Apoptosis was determined by JAM assay and DAPI staining analysis. Activation of key apoptotic proteins, including caspases...