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Contact of wear particles with body fluids can result in widespread dissemination of extractable constituents from joint implants. The aim of this in vitro study is to clarify whether there is a mutagenic and/or carcinogenic risk from CoCrMo and Ti6Al wear particles. Particles of a representative size were produced by fretting; toxicity and mutagenicity were investigated using the salmonella/microsome...
Durch den Kontakt von Abriebpartikeln mit Krperflssigkeiten knnen extrahierbare Bestandteile von Endoprothesen weit umverteilt werden. Die vorliegende in vitro- Untersuchung dient der Abklrung eines mglichen mutagenenen und karzinogenen Risikos von CoCrMo- (hier: Co28Cr6Mo-) und TiAl- (hier: Ti6Al4V-) Abriebpartikeln. Die Herstellung von Abriebpartikeln reprsentativer Gre erfolgte nach dem Reibverschleiverfahren,...
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