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A new flavonoid glycoside, an apigenin 7-O-(3,4-di-O-acetyl)-α-L-rhamnopyranosyl-(1 → _6)-β-D- glucopyranoside (1), was isolated from the 95% ethanol extract of Galium verum L. Its structure was elucidated by spectroscopic analysis.
Tenofovir octadecyloxyethyl ester (TOE) is a novel ester prodrug of tenofovir. It is currently developed as a promising antiviral preclinical candidate. A simple and sensitive liquid chromatography–tandem mass spectrometry (LC–MS–MS) method has been developed and validated to quantify TOE in rat plasma. The method involves a simple extraction of TOE and loratadine (internal standard) from rat plasma...
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