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Long-term bone marrow culture (LTBMC) supports both differentiation and conservation of hematopoietic progenitor cells. During the culture period, the frequency and proliferative potential of early repopulating stem cells that give rise to progenitors detectable after 5weeks in LTBMC so-called long-term culture-initiating cells (LTC-IC) can be investigated. The adherent stroma cell layer was modified...