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O-(2-fluoroethyl)-l-tyrosine (FET) labeled with fluorine-18 is an important and specific tracer for diagnostics of glioblastoma via positron emission tomography (PET). However, the mechanism of its quite specific accumulation in tumor tissue has not been understood so far. In this work we demonstrate that [3H]l-tyrosine is primarily transported by the system L transporter LAT1 in human LN229 glioblastoma...