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After a period of euphoria following the report on the first ex vivo production of monoclonal antibodies (Köhler, 1975), the new “magic bullets” as they were qualified by the press, however did not keep theirs promise. Indeed, apart OKT3 a mouse mAb directed against the T lymphocyte CD3 molecule, the first to get US and European approvals in the prevention of organ rejection in 1986, several trials...
Myelodysplastic syndromes (MDS) constitute a preneoplastic condition in which potentially malignant cancer stem cells continuously die during differentiation. This MDS-associated cell death often involves caspase-3 activation, yet can also occur without caspase activation, for instance in differentiating megakaryocytes (MK). We investigated, the mechanisms through which MK from MDS patients undergo...
The susceptibility of cells to apoptosis induction is deeply influenced by their position in the cell cycle. Unfortunately, however, current methods for the enrichment of cells in defined phases of the cell cycle are mostly based on the synchronization of cells by agents or conditions that are intrinsically toxic and induce apoptosis on their own. We developed a novel procedure for the purification...
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