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“From Hippocrates to the present age, it is universally allowed that ulcerated cartilage is a troublesome thing and that, once destroyed, is not repaired.” The Scottish physician William Hunter said this in a paper presented to the Royal Society in 1743. Over 260 years later, articular cartilage lesions of the knee remain a “troublesome thing.” Articular cartilage defects (ACDs) of the knee are frequently...