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Rationale Substance P antagonists have been proposed as candidates for a new class of antidepressant compounds. Objectives We examined the effects of SLV-323, a novel neurokinin 1 receptor (NK1R) antagonist, in the chronic psychosocial stress paradigm of adult male tree shrews. Methods Animals were subjected to a 7 day period of psychosocial stress before being treated daily with SLV-323 (20 mg kg...
Rationale Substance P and its preferred receptor, the neurokinin 1 receptor (NK1R), have been proposed as possible targets for new antidepressant therapies, although results of a recently completed phase III trial failed to demonstrate that the NK1R antagonist MK-869 is more effective than placebo in the treatment of depression. Methods In the present study, we compared the effects of the NK1R antagonist...
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