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A microfluidic chip was designed to produce with four different cell densities after seeding has been fabricated by soft lithography. It consists of eight parallel chambers with a single inlet and a single outlet. Each chamber was divided into four compartments, separated by a row of pillars. Human mesenchymal stem cells (hMSCs) were first grown on-chip using a normal culture medium for one day. Then,...
During development as well as in pathological situations, neurons that fail to find appropriate targets or neurotrophic factors undergo cell death. Using primary cortical neurons subjected to acute serum-deprivation (SD), we have examined caspases activation, mitochondrial dysfunction and cell death parameters. Among a panel of metabolic, signaling and caspases inhibitors only those able to interfere...
We describe here a cytofluorometric technology for the characterization of decision, execution, and degradation steps of neuronal apoptosis. Multiparametric flow cytometry was developped and combined to detailled fluorescence microscopy observations to establish the chronology and hierarchy of death-related events: neuron morphological changes, mitochondrial transmembrane potential (Δ Ψm) collapse,...
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