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The sensing performance of DNAzymes in live cells is tremendously hampered by the inefficient and inhomogeneous delivery of DNAzyme probes and their incontrollable off‐site activation, originating from their susceptibility to nuclease digestion. This requires the development of a more compact and robust DNAzyme‐delivering system with site‐specific DNAzyme activation property. Herein, a highly compact...
Trace analyte detection in complex intracellular environment requires the development of simple yet robust self‐sufficient molecular circuits with high signal‐gain and anti‐interference features. Herein, a minimal non‐enzymatic self‐replicate DNA circuitry (SDC) system is proposed with high‐signal‐gain for highly efficient biosensing in living cells. It is facilely engineered through the self‐stacking...
DNA amplification machines show great promise for intracellular imaging, yet are always constrained by off‐site machinery activation or signal leakage, originating from the inherent thermodynamically driven hybridization between machinery substrates. Herein, an entropy‐driven catalytic DNA amplification machine is integrated with the on‐site amplified substrate exposure procedure to realize the high‐contrast...
Probing endogenous molecular profiles in living entities is of fundamental significance to decipher biological functions and exploit novel theranostics. Despite programmable nucleic acid‐based aptasensing systems across the breadth of molecular imaging, an aptasensing system enabling in vivo imaging with high sensitivity, accuracy, and adaptability is highly required yet is still in its infancy. Artificial...
Nanozyme has emerged as a versatile nanocatalyst yet is constrained with limited catalytic efficiency and specificity for various biomedical applications. Herein, by elaborately integrating the recognition/transduction carbon dots (CDs) with platinum nanoparticles (PtNPs), an exquisite CDs@PtNPs (CPP) nanoflare is engineered as an efficient and substrate‐specific peroxidase‐mimicking nanozyme for...
Nanobactericides represent one of the most efficient and promising strategies for eliminating bacterial infection considering the increasing resistance threats of conventional antibiotics. Black phosphorus (BP) is the most exciting postgraphene layered 2D nanomaterial with convincing physiochemical properties, yet the study of BP‐based antibiotics is still in its infancy. Here, a compact silver nanoparticle...
In article number 1903266, Fuan Wang and co‐workers construct a mitochondria‐specific lighting up fluorescent Mito‐Cy, that is capable of spatiotemporally tracking the programmable mitochondrial membrane potential (MMP) evolutions in live cells, thus holding great promise for illustrating mitochondria‐involved pathophysiological pathways.
Mitochondrial membrane potential (MMP) represents an essential parameter of cellular activities, and even a minute MMP variation could significantly affect the biological functions of living organisms. Thus, convenient and accurate MMP detection is highly desirable since conventional MMP probes are always constrained by photobleaching, inconvenience, and irreversibility. Herein, a spatial‐dependent...
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