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Trace analyte detection in complex intracellular environment requires the development of simple yet robust self‐sufficient molecular circuits with high signal‐gain and anti‐interference features. Herein, a minimal non‐enzymatic self‐replicate DNA circuitry (SDC) system is proposed with high‐signal‐gain for highly efficient biosensing in living cells. It is facilely engineered through the self‐stacking...
In article number 1903266, Fuan Wang and co‐workers construct a mitochondria‐specific lighting up fluorescent Mito‐Cy, that is capable of spatiotemporally tracking the programmable mitochondrial membrane potential (MMP) evolutions in live cells, thus holding great promise for illustrating mitochondria‐involved pathophysiological pathways.
Mitochondrial membrane potential (MMP) represents an essential parameter of cellular activities, and even a minute MMP variation could significantly affect the biological functions of living organisms. Thus, convenient and accurate MMP detection is highly desirable since conventional MMP probes are always constrained by photobleaching, inconvenience, and irreversibility. Herein, a spatial‐dependent...
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