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While research in youth mentoring is extensive in the U.S., little research has explored its effectiveness in New Zealand, despite its growth in the past 20 years. While arguments have been raised that overseas models may not fit all cultural contexts within New Zealand, there appears to be limited evidence supporting this contention. Further, little is known about associations between effectiveness...
Kinetochore components have catalytic as well as structural activities. New evidence illustrates how these proteins integrate spindle morphogenesis with regulation of the timing and accuracy of chromosome segregation.
Abstract. Genetic analysis of microtubule functions in the yeast Saccharomyces cerevisiae suggests that cells manage the levels and activities of the tubulin polypeptides. These reactions may be involved in protein folding, formation of the heterodimer, and maintenance of the appropriate balance between - and -tubulin. One protein involved in these functions is Rbl2p, which forms a complex with -tubulin...
Genetic configurations resulting in high ratios of β-tubulin to α-tubulin are toxic in S. cerevisiae, causing microtubule disassembly and cell death. We identified three non-tubulin yeast genes that, when overexpressed, rescue cells from excess β-tubulin. One, RBL2, rescues β-tubulin lethality as efficiently as does α-tubulin. Rbl2p binds to β-tubulin in vivo. Deficiencies or excesses of either RbI2p...
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