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Parasite infections are diverse, complex and widespread, and they represent major health threats to people and animals alike. Topics such as vaccine development, drug resistance, immune regulation, vector-borne parasitic diseases, and wildlife parasitology are key issues. Here, we discuss the need and direction of structured educational programs for graduates in modern parasitology.
In higher order organisms, cell-to-cell interactions are crucial to fulfill concerted, tissue-or organ-specific tasks. Three-dimensional cell culture models reflect the natural environment of tissue structures in a more realistic way than cells in traditional monolayer cultures. By combining an automatable microtissue technology with a cell based assay, cell viability, cytotoxicity and the number...
The majority of early immature B cells express autoreactive B cell receptors (BCRs) that are, according to the current view, negatively selected to avoid the production of self-reactive antibodies. Here, we show that polyreactive BCRs, which recognize multiple self-antigens, induced autonomous signaling and selective expansion of B cell precursors in a manner comparable to the pre-BCR. We found that...
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