Search results for: Takeshi Yaoi

Items from 1 to 20 out of 22 results

article

Leukemia inhibitory factor shortens primary cilia by upregulating C‐C motif chemokine 2 in human neural stem/progenitor cells

Hisashi Takahashi, Takahiro Fujimoto, Takeshi Yaoi, Shinji Fushiki, more

Primary cilia on neural stem/progenitor cells (NSPCs) play an important role in determining cell fate, although the regulatory mechanisms involved in the ciliogenesis remain largely unknown. In this study, we analyzed the effect of the leukemia inhibitory factor (LIF) for the primary cilia in immortalized human NSPCs. LIF withdrawal elongated the primary cilia length, whereas the addition of LIF shortened...

article

An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with TDP‐43 proteinopathy, associated with Alzheimer's disease pathology

So Tando, Takashi Kasai, Ikuko Mizuta, Hisashi Takahashi, more

Neuropathology > 41 > 3 > 214 - 225

We herein report a case of corticobasal syndrome (CBS) due to asymmetric degeneration of the motor cortex and substantia nigra with transactivation response DNA‐binding protein of 43 kDa (TDP‐43) proteinopathy, associated with Alzheimer's disease (AD) pathology. An 85‐year‐old man initially noticed that he had difficulty in walking and had trouble in moving his right hand and lower limb one year later...

article

Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells

Takahiro Fujimoto, Takeshi Yaoi, Shinji Fushiki, Kyoko Itoh

Biochemical and Biophysical Research Communications > 2017 > 492 > 3 > 349-355

The Dystrophin (Dp) gene is responsible for Duchenne muscular dystrophy (DMD), which is characterized by progressive muscular degeneration and variable degrees of cognitive impairment. Although Dp71 is the most abundant among the Dp isoforms in the brain, the regulatory mechanisms of the related expression levels have not been elucidated. In this study, we found that the constitutive expression levels...

article

Bisphenol A exposure disrupts the development of the locus coeruleus‐noradrenergic system in mice

So Tando, Kyoko Itoh, Takeshi Yaoi, Hiroshi Ogi, more

Neuropathology > 34 > 6 > 527 - 534

It has been reported that bisphenol A (BPA), a widespread xenoestrogen employed in the production of polycarbonate plastics, affects brain development in both humans and rodents. In the present study employing mice, we examined the effects of exposure to BPA (500 μg/kg/day) during fetal and lactational periods on the development of the locus coeruleus (LC) at the age of embryonic day 18 (E18), postnatal...

article

Somatodendritic and excitatory postsynaptic distribution of neuron-type dystrophin isoform, Dp40, in hippocampal neurons

Takahiro Fujimoto, Kyoko Itoh, Takeshi Yaoi, Shinji Fushiki

Biochemical and Biophysical Research Communications > 2014 > 452 > 1 > 79-84

The Duchenne muscular dystrophy (DMD) gene produces multiple dystrophin (Dp) products due to the presence of several promoters. We previously reported the existence of a novel short isoform of Dp, Dp40, in adult mouse brain. However, the exact biochemical expression profile and cytological distribution of the Dp40 protein remain unknown. In this study, we generated a polyclonal antibody against the...

article

Downregulation of L1 perturbs neuronal migration and alters the expression of transcription factors in murine neocortex

Tomokazu Kishimoto, Kyoko Itoh, Masafumi Umekage, Madoka Tonosaki, more

Journal of Neuroscience Research > 91 > 1 > 42 - 50

L1 is a cell adhesion molecule associated with a spectrum of human neurological diseases, the most well‐known being X‐linked hydrocephalus. L1 knockout (L1‐KO) mice have revealed a variety of functions of L1 that were crucial in brain development in different brain regions. However; the function of L1 in neuronal migration during cortical histogenesis remains to be clarified. We therefore investigated...

article

Bisphenol A, an endocrine‐disrupting chemical, and brain development

Kyoko Itoh, Takeshi Yaoi, Shinji Fushiki

Neuropathology > 32 > 4 > 447 - 457

Bisphenol A (BPA) is an endocrine‐disrupting chemical, widely used in various industries and the field of dentistry. The consequent increase in BPA exposure among humans has led us to some concerns regarding the potential deleterious effects on reproduction and brain development. The emphasis of this review is on the effects of prenatal and lactational exposure to low doses of BPA on brain development...

article

The Shortest Isoform of Dystrophin (Dp40) Interacts with a Group of Presynaptic Proteins to Form a Presumptive Novel Complex in the Mouse Brain

Takenori Tozawa, Kyoko Itoh, Takeshi Yaoi, So Tando, more

Molecular Neurobiology > 2012 > 45 > 2 > 287-297

Duchenne muscular dystrophy (DMD) causes cognitive impairment in one third of the patients, although the underlying mechanisms remain to be elucidated. Recent studies showed that mutations in the distal part of the dystrophin gene correlate well with the cognitive impairment in DMD patients, which is attributed to Dp71. The study on the expression of the shortest isoform, Dp40, has not been possible...

article

Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A

Takeshi Yaoi, Kyoko Itoh, Keiko Nakamura, Hiroshi Ogi, more

Biochemical and Biophysical Research Communications > 2008 > 376 > 3 > 563-567

Bisphenol A (BPA) is one of endocrine disrupting chemicals, being distributed widely in the environment. We have been studying the low dose effects of BPA on murine forebrain development. Here, we have investigated the genome-wide effect of maternal exposure to BPA on the epigenome in mouse forebrain at E12.5 and at E14.5. We scanned CpG methylation status in 2500 NotI loci, representing 48 (de)methylated...

article

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans

Akira Fujimori, Takeshi Yaoi, Hiroshi Ogi, Bing Wang, more

Biochemical and Biophysical Research Communications > 2008 > 369 > 3 > 953-957

Microcephaly is a malformation associated with in utero exposed atomic bomb survivors and can be induced in mice by fetal exposure to ionizing radiation (IR). The pathogenesis of IR-induced microcephaly, however, has not been fully understood. Our analyses of high-coverage expression profiling (HiCEP) demonstrated that the abnormal spindle-like microcephaly associated gene (ASPM) was down-regulated...

article

Effects of pre- and neonatal exposure to bisphenol A on murine brain development

So Tando, Kyoko Itoh, Takeshi Yaoi, Jun Ikeda, more

Brain and Development > 2007 > 29 > 6 > 352-356

Bisphenol A (BPA), known as an environmental endocrine disrupter, is widely used in industry and dentistry. We investigated the effects of fetal and neonatal exposure to bisphenol A (BPA) on the brain development of mice. The density of tyrosine hydroxylase (TH)-immunoreactive (IR) neurons in substantia nigra was significantly decreased in BPA-exposed female mice (3μg/g powder food), but not in the...

article

What we do for neurodevelopmental diseases with epigenetic disorders

Shinji Fushiki, Takeshi Yaoi, Keiko Nakamura, Kyoko Itoh

Neuroscience Research > 2007 > 58 > Supplement 1 > S7

article

Cancer-associated loss of TARSH gene expression in human primary lung cancer

Kunihiko Terauchi, Junichi Shimada, Natsuko Uekawa, Takeshi Yaoi, more

Journal of Cancer Research and Clinical Oncology > 2006 > 132 > 1 > 28-34

Purpose: We have previously identified mouse Tarsh as one of the cellular senescence-related genes and showed the loss of expression of TARSH mRNA in four human lung cancer cell lines. TARSH is a presumptive signal transduction molecule interacting with NESH, which is implicated to have some roles in lung cancer metastasis. Methods: The amplification of complete ORF-encoding TARSH cDNA was done with...

article

Spatiotemporal patterns of expression of IGSF4 in developing mouse nervous system

Yoshimi Ohta, Kyoko Itoh, Takeshi Yaoi, So Tando, more

Developmental Brain Research > 2005 > 156 > 1 > 23-31

IGSF4 is a novel immunoglobulin (Ig)-like intercellular adhesion molecule. Since IGSF4 has been characterized by several independent research groups, this molecule is called by three names, TSLC1, SgIGSF and SynCAM. In the experiments to study global changes of gene expression in fetal murine brains after prenatal exposure to low-doses of X-rays, we have found IGSF4 as one of down-regulated genes...

article

A novel marker for terminal Schwann cells, homocysteine-responsive ER-resident protein, as isolated by a single cell PCR-differential display

Ryo Oda, Takeshi Yaoi, Seiichiro Okajima, Hiroaki Kobashi, more

Biochemical and Biophysical Research Communications > 2003 > 308 > 4 > 872-877

Terminal Schwann cells (TSCs) that cover motor neuron terminals are known to play important roles in maintaining neuromuscular junctions, as well as in the repair process after nerve injury. However, molecular characteristics of TSCs remain unknown, because of the difficulties in analyzing them due to their paucity. We have established a method of selectively and efficiently collecting TSCs so that...

article

Antisense oligonucleotide for tissue factor inhibits hepatic ischemic reperfusion injury

Kenji Nakamura, Yayoi Kadotani, Hidetaka Ushigome, Kiyokazu Akioka, more

Biochemical and Biophysical Research Communications > 2002 > 297 > 3 > 433-441

Tissue factor (TF) is an initiation factor for blood coagulation and its expression is induced on endothelial cells during inflammatory or immune responses. We designed an antisense oligodeoxynucleotide (AS-1/TF) for rat TF and studied its effect on hepatic ischemic reperfusion injury. AS-1/TF was delivered intravenously to Lewis rats. After 10h, hepatic artery and portal vein were partially clamped...

article

Up-Regulated Uridine Kinase Gene Identified by RLCS in the Ventral Horn after Crush Injury to Rat Sciatic Nerves

Inhaeng Yuh, Takeshi Yaoi, Sachihiko Watanabe, Seiichiro Okajima, more

Biochemical and Biophysical Research Communications > 1999 > 266 > 1 > 104-109

Rat sciatic nerve crush injury is one of the models commonly employed for studying the mechanisms of nerve regeneration. In this study, we analyzed the temporal change of gene expression after injury in this model, to elucidate the molecular mechanisms involved in nerve regeneration. First, a cDNA analysis method, Restriction Landmark cDNA Scanning (RLCS), was applied to cells in the ventral horn...

article

Ca ² ⁺ -dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma

Takashi Nakayama, Takeshi Yaoi, Goro Kuwajima, Osamu Yoshie, more

FEBS Letters > 1999 > 453 > 1-2 > 77-80

N-copine is a novel two C2 domain protein that shows Ca ² ⁺ -dependent phospholipid binding and membrane association. By using yeast two-hybrid assays, we identified OS-9 as a protein capable of interacting with N-copine. We further revealed that the second C2 domain of N-copine bound with the carboxy-terminal region of OS-9. Their interaction in vivo was also confirmed by co-immunoprecipitation...

article

Improved restriction landmark cDNA scanning and its application to global analysis of genes regulated by nerve growth factor in PC12 cells

Keiko Mayumi, Takeshi Yaoi, Jun Kawai, Satoshi Kojima, more

BBA - Gene Structure and Expression > 1998 > 1399 > 1 > 10-18

Restriction landmark cDNA scanning (RLCS) is a novel method by which more than 1000 genes can be simultaneously and quantitatively displayed as two-dimensional gel spots. Here we present an adaptation that allows an individual spot to correspond to a unique gene species without redundancy in more than two gel patterns. Using this improved RLCS, we examined global changes on the gene expression of...

article

N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression

Takashi Nakayama, Takeshi Yaoi, Mitsuru Yasui, Goro Kuwajima

FEBS Letters > 1998 > 428 > 1-2 > 80-84

Neuronal activity is often associated with changes in gene expression. By a two-dimensional cDNA-display system, restriction landmark cDNA scanning, we identified a novel gene whose expression in the hippocampus was up-regulated by kainate stimulation. The mRNA expression was detected only in brain and up-regulated by the stimulation evoking CA3-CA1 long-term potentiation. The encoded protein contains...

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INFONA - science communication portal

Search results for: Takeshi Yaoi

Leukemia inhibitory factor shortens primary cilia by upregulating C‐C motif chemokine 2 in human neural stem/progenitor cells

An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with TDP‐43 proteinopathy, associated with Alzheimer's disease pathology

Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells

Bisphenol A exposure disrupts the development of the locus coeruleus‐noradrenergic system in mice

Somatodendritic and excitatory postsynaptic distribution of neuron-type dystrophin isoform, Dp40, in hippocampal neurons

Downregulation of L1 perturbs neuronal migration and alters the expression of transcription factors in murine neocortex

Bisphenol A, an endocrine‐disrupting chemical, and brain development

The Shortest Isoform of Dystrophin (Dp40) Interacts with a Group of Presynaptic Proteins to Form a Presumptive Novel Complex in the Mouse Brain

Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans

Effects of pre- and neonatal exposure to bisphenol A on murine brain development

What we do for neurodevelopmental diseases with epigenetic disorders

Cancer-associated loss of TARSH gene expression in human primary lung cancer

Spatiotemporal patterns of expression of IGSF4 in developing mouse nervous system

A novel marker for terminal Schwann cells, homocysteine-responsive ER-resident protein, as isolated by a single cell PCR-differential display

Antisense oligonucleotide for tissue factor inhibits hepatic ischemic reperfusion injury

Up-Regulated Uridine Kinase Gene Identified by RLCS in the Ventral Horn after Crush Injury to Rat Sciatic Nerves

Ca ² ⁺ -dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma

Improved restriction landmark cDNA scanning and its application to global analysis of genes regulated by nerve growth factor in PC12 cells

N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression

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