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Transient receptor potential vanilloid 1 (TRPV1) is a member of the transient receptor potential (TRP) family of proteins and is most notably the target of capsaicin, the active ingredient of “hot” pepper such as jalapeño and habanero. The channel is expressed primarily in small diameter neurons (Aδ and C fibers) within sensory ganglia comprising the pain pathway but expression is observed in larger...
Cisplatin is a widely used chemotherapeutic agent that causes significant hearing loss. Previous studies have shown that cisplatin exposure is associated with increase in reactive oxygen species (ROS) in the cochlea. The inner ear expresses a unique isoform of NADPH oxidase, NOX3. This enzyme may be the primary source of ROS generation in the cochlea. The knockdown of NOX3 by pretreatment with siRNA...
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