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Various members of the bZip and bHLH-Zip families of eukaryotic transcription factors,including Jun, Fos, and Myc, have been identified as oncoproteins; mutation or deregulatedexpression of these proteins leads to certain types of cancer. These proteins can only bind totheir cognate DNA enhancer sites following homodimerization, or heterodimerization withanother family member, via their leucine zipper...