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Aims/hypothesis The molecular mechanisms by which thiazolidinediones improve insulin sensitivity in type 2 diabetes are not fully understood. We hypothesised that pioglitazone would activate the adenosine 5′-monophosphate-activated protein kinase (AMPK) pathway and increase the expression of genes involved in adiponectin signalling, NEFA oxidation and mitochondrial function in human skeletal muscle...
L’exénatide diminue de façon marquée l’hyperglycémie postprandiale (PP) et plus modestement la glycémie à jeun (GAJ).Afin d’explorer les mécanismes impliqués, 6 patients diabétiques de type 2 (DT2) (45±8 ans ; 2F/4H ; IMC 31±2 kg/m 2 ; HbA1c 8,1±0,8 %) sous metformine (n=3) ou sulfamide (n=3) ont reçu un repas test avant (PRE) et 2 semaines après (POST) un traitement sous-cutané par exénatide...
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