Search results for: Anne B. Need

Items from 1 to 6 out of 6 results

article

In vivo rat brain opioid receptor binding of LY255582 assessed with a novel method using LC/MS/MS and the administration of three tracers simultaneously

Anne B. Need, Jamie H. McKinzie, Charles H. Mitch, Michael A. Statnick, more

Life Sciences > 2007 > 81 > 17-18 > 1389-1396

LY255582 is a pan opioid selective receptor antagonist that has been shown to have high affinity for mu, delta, and kappa receptors in vitro. In order to better understand the in vivo opioid receptor selectivity of LY255582, we developed in vivo receptor occupancy assays in the rat for the opioid mu, kappa and delta receptors using the occupancy tracers naltrexone, GR103545 and naltriben respectively...

article

Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: Evidence for synergism between serotonergic and noradrenergic reuptake inhibition

Carrie K. Jones, Brian J. Eastwood, Anne B. Need, Harlan E. Shannon

Neuropharmacology > 2006 > 51 > 7-8 > 1172-1180

The efficacy of antidepressant drugs with serotonergic, noradrenergic, or dual reuptake inhibition was evaluated in reversing carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats. Duloxetine (1–30mg/kg, i.p.), a balanced serotonergic–noradrenergic reuptake inhibitor (SNRI), was equiefficacious and more potent than the SNRI venlafaxine (3–100mg/kg, i.p.) in reversing both thermal...

article

Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer

Vanessa N. Barth, Eyassu Chernet, Laura J. Martin, Anne B. Need, more

Life Sciences > 2006 > 78 > 26 > 3007-3012

Preclinical brain receptor occupancy measures have heretofore been conducted by quantifying the brain distribution of a radiolabeled tracer ligand using either scintillation spectroscopy or tomographic imaging. For smaller animals like rodents, the majority of studies employ tissue dissection and scintillation spectroscopy. These measurements can also be accomplished using liquid chromatography coupled...

article

The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats

Anne B. Need, Richard J. Davis, Jesline T. Alexander-Chacko, Brian Eastwood, more

Psychopharmacology > 2006 > 184 > 1 > 26-35

Rationale Cannabinoid type 1 (CB₁) receptor antagonists are reportedly effective in reducing food intake both preclinically and clinically. This may be due in part to their effects on monoamine release in the brain. The level of central CB₁ receptor occupancy underlying these neurobiological effects is unclear. Objectives We explored the relationship between in vivo CB₁ receptor occupancy in the...

article

Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: Dopamine D2, serotonin 2A and NK-1 receptors as examples

Eyassu Chernet, Laura J. Martin, Dominic Li, Anne B. Need, more

Life Sciences > 2005 > 78 > 4 > 340-346

High performance liquid chromatography combined with either single quad or triple quad mass spectral detectors (LC/MS) was used to measure the brain distribution of receptor occupancy tracers targeting dopamine D2, serotonin 5-HT2A and neurokinin NK-1 receptors using the ligands raclopride, MDL-100907 and GR205171, respectively. All three non-radiolabeled tracer molecules were easily detectable in...

article

Enhancement of Antidepressant Potency by a Potentiator of AMPA Receptors

Xia Li, Jeffrey M. Witkin, Anne B. Need, Phil Skolnick

Cellular and Molecular Neurobiology > 2003 > 23 > 3 > 419-430

1. AMPA receptor potentiators (ARPs) exhibit antidepressant-like activity in preclinical tests (for example, the forced swim test) that are highly predictive of efficacy in humans. Unlike most currently used antidepressants, ARPs do not elevate extracellular levels of biogenic amines (e.g., 5HT, NE) in prefrontal cortex at doses that are active in the forced swim test. 2. The present series of experiments...

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Keywords

IN VIVO BINDING (4)
RECEPTOR OCCUPANCY (4)
DOPAMINE (3)
RAT (3)
CLOZAPINE (2)
D2 (2)
DULOXETINE (2)
HALOPERIDOL (2)
LIQUID CHROMATOGRAPHY (2)
MASS SPECTROSCOPY (2)
OLANZAPINE (2)
RACLOPRIDE (2)
5-HT2A (1)
AMPA RECEPTORS (1)
ANTIDEPRESSANTS (1)
BEHAVIORAL DESPAIR (1)
BIOGENIC AMINES (1)
CANNABINOID (1)
CARRAGEENAN TEST (1)
CHLORPROMAZINE (1)
CITALOPRAM (1)
FEEDING (1)
FLUOXETINE (1)
FORCED SWIM TEST (1)
GERBIL (1)
GR205171 (1)
IMIPRAMINE (1)
LY 392098 (1)
LY255582 (1)
MDL-100907 (1)
MICRODIALYSIS (1)
MIXED SEROTONERGIC–NORADRENERGIC REUPTAKE INHIBITION (1)
MK-869 (1)
NEUROKININ (1)
NISOXETINE (1)
NK-1 (1)
NORADRENERGIC REUPTAKE INHIBITION (1)
NOREPINEPHRINE (1)
OPIOID (1)
PERSISTENT PAIN (1)
RISPERIDONE (1)
ROLIPRAM (1)
SEROTONERGIC REUPTAKE INHIBITION (1)
SEROTONIN (1)
SLV319 (1)
SPIPERONE (1)
SR141716A (1)
STRIATUM (1)
THIORIDAZINE (1)
TRANYLCYPROMINE (1)
ZIPRASIDONE (1)
[3H]SR141716A (1)
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Elsevier (4)
Springer (2)

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Search results for: Anne B. Need

In vivo rat brain opioid receptor binding of LY255582 assessed with a novel method using LC/MS/MS and the administration of three tracers simultaneously

Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: Evidence for synergism between serotonergic and noradrenergic reuptake inhibition

Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer

The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats

Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: Dopamine D2, serotonin 2A and NK-1 receptors as examples

Enhancement of Antidepressant Potency by a Potentiator of AMPA Receptors

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INFONA - science communication portal

Search results for: Anne B. Need

In vivo rat brain opioid receptor binding of LY255582 assessed with a novel method using LC/MS/MS and the administration of three tracers simultaneously

Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: Evidence for synergism between serotonergic and noradrenergic reuptake inhibition

Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer

The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats

Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: Dopamine D2, serotonin 2A and NK-1 receptors as examples

Enhancement of Antidepressant Potency by a Potentiator of AMPA Receptors

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