Search results for: Dylan R. Edwards

Items from 1 to 20 out of 29 results

article

ADAMTS9, a member of the ADAMTS family, in Xenopus development

Ines Desanlis, Hannah L. Felstead, Dylan R. Edwards, Grant N. Wheeler

Gene Expression Patterns > 2018 > 29 > C > 72-81

Extracellular matrix (ECM) remodeling by metalloproteinases is crucial during development. The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin type I motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling. The human family includes 19 members. In this study we identified...

article

Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

Muge Sarper, Michael D. Allen, Jenny Gomm, Linda Haywood, more

Breast Cancer Research > 2017 > 19 > 1 > 1-19

Background Normal myoepithelial cells (MECs) play an important tumour-suppressor role in the breast but display an altered phenotype in ductal carcinoma in situ (DCIS), gaining tumour-promoter functions. Matrix metalloproteinase-8 (MMP-8) is expressed by normal MECs but is lost in DCIS. This study investigated the function of MMP-8 in MECs and the impact of its loss in DCIS. Methods Primary normal...

chapter

Tumor Fibroblast-Associated Metalloproteases

Julie Lecomte, Anne Masset, Dylan R. Edwards, Agnès Noël

The Tumor Microenvironment > Tumor-Associated Fibroblasts and their Matrix > The Tumor ECM > 175-193

Matrix metalloproteinases (MMPs) and the closely related ADAM (a disintegrin and metalloproteinase domain) and ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) are soluble or membrane-anchored proteolytic enzymes that can degrade components of the extracellular matrix (ECM) as well as a growing numbers of modulators of cell functions. Our knowledge about the multifaceted...

article

Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in Active Surveillance Patients

Colin S. Cooper, Jeremy Clark, Daniel S. Brewer, Dylan R. Edwards

European Urology > 2016 > 69 > 2 > 229-230

article

Proteases in cancer drug delivery

Jennifer Vandooren, Ghislain Opdenakker, Paul M. Loadman, Dylan R. Edwards

Advanced Drug Delivery Reviews > 2016 > 97 > C > 144-155

Whereas protease inhibitors have been developed successfully against hypertension and viral infections, they have failed thus far as cancer drugs. With advances in cancer profiling we now better understand that the tumor “degradome” (i.e. the repertoire of proteases and their natural inhibitors and interaction partners) forms a complex network in which specific nodes determine the global outcome of...

article

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice

Julie Decock, Wouter Hendrickx, Sally Thirkettle, Ana Gutiérrez-Fernández, more

Breast Cancer Research > 2015 > 17 > 1 > 1-13

Introduction Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity that has oncosuppressive actions in numerous tumor types. Methods We have intercrossed Mmp8-null mice with the Polyoma virus middle T oncogene-driven (MMTV-PyMT) mouse model of mammary cancer to explore the effects of loss of MMP-8 on the incidence and progression of mammary carcinomas...

article

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

Richard Kelwick, Ines Desanlis, Grant N Wheeler, Dylan R Edwards

Genome Biology > 2015 > 16 > 1 > 1-16

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology. The human family includes 19 members that can be sub-grouped on the basis of their known substrates, namely the aggrecanases...

article

Metalloproteinase‐dependent and ‐independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs‐15

Richard Kelwick, Laura Wagstaff, Julie Decock, Christian Roghi, more

International Journal of Cancer > 136 > 4 > E14 - E26

The ADAMTS proteinases are a family of secreted, matrix‐associated enzymes that have diverse roles in the regulation of tissue organization and vascular homeostasis. Several of the 19 human family members have been identified as having either tumor promoting or suppressing roles. We previously demonstrated that decreased ADAMTS15 expression correlated with a worse clinical outcome in mammary carcinoma...

article

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

Suzanne A Eccles, Eric O Aboagye, Simak Ali, Annie S Anderson, more

Breast Cancer Research > 2013 > 15 > 5 > 1-37

Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals...

article

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes

Matt J. Barter, Leon Pybus, Gary J. Litherland, Andrew D. Rowan, more

Matrix Biology > 2010 > 29 > 7 > 602-612

Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-β signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in mouse C3H10T1/2 fibroblasts suggested that a number of TGF-β-induced genes that regulate matrix turnover are selectively regulated by HDACs. Blockade...

article

Avoiding spam in the proteolytic internet: Future strategies for anti-metastatic MMP inhibition

Achim Krüger, Ronald E. Kates, Dylan R. Edwards

BBA - Molecular Cell Research > 2010 > 1803 > 1 > 95-102

Phase III clinical trials with cancer patients with the first generation of synthetic MMP inhibitors (MMPIs) failed due to inefficacy and adverse side effects. These results were unexpected, given the wealth of pre-clinical data implicating MMPs as cancer targets, but are attributable to the broad-spectrum activity of these early MMPIs and the limited knowledge of the variety of biological functions...

article

Brk Protects Breast Cancer Cells from Autophagic Cell Death Induced by Loss of Anchorage

Amanda J. Harvey, Caroline J. Pennington, Sarah Porter, Rajpal S. Burmi, more

The American Journal of Pathology > 2009 > 175 > 3 > 1226-1234

Brk, a tyrosine kinase expressed in a majority of breast tumors, but not normal mammary tissue, promotes breast carcinoma cell proliferation. Normal epithelial cells are dependent on cell–cell or cell–matrix interactions for survival and undergo apoptosis after disruption of these interactions. Tumor cells are less sensitive to the induction of apoptosis and are predicted to have the potential to...

article

Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms

Rachael A Hancox, Michael D Allen, Deborah L Holliday, Dylan R Edwards, more

Breast Cancer Research > 2009 > 11 > 2 > 1-13

Introduction The stromal microenvironment has a profound influence on tumour cell behaviour. In tumours, the extracellular matrix (ECM) composition differs from normal tissue and allows novel interactions to influence tumour cell function. The ECM protein tenascin-C (TNC) is frequently up-regulated in breast cancer and we have previously identified two novel isoforms – one containing exon 16 (TNC-16)...

article

The ADAM metalloproteinases

Dylan R. Edwards, Madeleine M. Handsley, Caroline J. Pennington

Molecular Aspects of Medicine > 2008 > 29 > 5 > 258-289

The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane and secreted proteins with important roles in regulating cell phenotype via their effects on cell adhesion, migration, proteolysis and signalling. Though all ADAMs contain metalloproteinase domains, in humans only 13 of the 21 genes in the family encode functional proteases, indicating that at least for the other...

article

The regulation of matrix metalloproteinases and their inhibitors

Ian M. Clark, Tracey E. Swingler, Clara L. Sampieri, Dylan R. Edwards

International Journal of Biochemistry and Cell Biology > 2008 > 40 > 6-7 > 1362-1378

The matrix metalloproteinases (MMP) are a family of 23 enzymes in man. These enzymes were originally described as cleaving extracellular matrix (ECM) substrates with a predominant role in ECM homeostasis, but it is now clear that they have much wider functionality. Control over MMP and/or tissue inhibitor of metalloproteinases (TIMP) activity in vivo occurs at different levels and involves factors...

article

Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes

Clara L. Sampieri, Robert K. Nuttall, David A. Young, Deborah Goldspink, more

Matrix Biology > 2008 > 27 > 2 > 128-138

The human matrix metalloproteinase (MMP) gene family includes 24 genes whose regulated expression, together with that of four tissue inhibitors of metalloproteinases (TIMPs), is essential in tissue remodelling and cell signalling. Quantitative real-time-PCR (qPCR) analysis was used to evaluate the shared and unique patterns of control of these two gene families in human MRC-5 and WI-38 fibroblasts...

article

Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3

Robert J.R. Singh, Justin C. Mason, Elaine A. Lidington, Dylan R. Edwards, more

Cardiovascular Research > 2005 > 67 > 1 > 39-49

Vascular cell adhesion molecule-1 (VCAM-1) is a cell surface adhesion molecule involved in the recruitment of leukocytes to endothelial cells on arterial walls during the pathogenesis of atherosclerosis. The soluble ectodomain of VCAM-1 (sVCAM-1) is proteolytically released from the cell surface into the circulation, a process which is up-regulated in patients with cardiovascular or inflammatory disease...

article

Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

David A. Young, Svetlana Gavrilov, Caroline J. Pennington, Robert K. Nuttall, more

Biochemical and Biophysical Research Communications > 2004 > 322 > 3 > 759-765

P19CL6 are a clonal derivative of P19 embryonal carcinoma cells, a euploid, multipotent mouse cell line, that differentiate efficiently into cardiac myocytes, with spontaneous beating evident within 10 days, following DMSO treatment. Using real-time quantitative RT-PCR we have profiled the expression of the complete matrix metalloproteinase and tissue inhibitor of metalloproteinase gene families during...

article

Expression analysis of the entire MMP and TIMP gene families during mouse tissue development

Robert K. Nuttall, Clara L. Sampieri, Caroline J. Pennington, Sean E. Gill, more

FEBS Letters > 2004 > 563 > 1-3 > 129-134

Matrix metalloproteinases (MMPs) and adamalysins (ADAMs) cleave many extracellular proteins, including matrix, growth factors, and receptors. We profiled the RNA levels of every MMP, several ADAMs, and inhibitors of metalloproteinases (TIMPs and RECK) in numerous mouse tissues during development and in the uterus during pregnancy. Observations include: most secreted MMPs are expressed at low to undetectable...

article

Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment

Léon C.L. van Kempen, Jin-Sae Rhee, Kerstin Dehne, Jake Lee, more

Differentiation > 2002 > 70 > 9-10 > 610-623

Matrix metalloproteinases (MMPs) have long been thought of as critical factors regulating matrix degradation associated with cell invasion into ectopic tissue compartments during primary tumor growth and metastasis. One member of the MMP family historically linked to these invasive processes is MMP-9/gelatinase B. By studying a transgenic mouse model of de novo epithelial carcinogenesis, new roles...

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Search results for: Dylan R. Edwards

ADAMTS9, a member of the ADAMTS family, in Xenopus development

Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

Tumor Fibroblast-Associated Metalloproteases

Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in Active Surveillance Patients

Proteases in cancer drug delivery

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

Metalloproteinase‐dependent and ‐independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs‐15

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes

Avoiding spam in the proteolytic internet: Future strategies for anti-metastatic MMP inhibition

Brk Protects Breast Cancer Cells from Autophagic Cell Death Induced by Loss of Anchorage

Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms

The ADAM metalloproteinases

The regulation of matrix metalloproteinases and their inhibitors

Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes

Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3

Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

Expression analysis of the entire MMP and TIMP gene families during mouse tissue development

Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment

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