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The optimal method of assessing GH status in acromegalic patients receiving medical therapy with somatostatin analogs (SSA) has been matter of debate. The aim of the study has been to investigate whether OGTT may add information in patients with discordant random GH (GHr) and IGF values. Moreover, we evaluated the association of GH nadir with the prevalence of co-morbidities observed in acromegalic...
Cushing’s syndrome is associated with high cardiovascular morbility and mortality. Blood pressure (BP) variability within a 24-h period is increasingly recognized as an independent predictor of cardiovascular risk. The aim of our study was to investigate the short-term BP variability indices in Cushing’s syndrome. Twenty-five patients with Cushing’s syndrome (mean age 49 ± 13 years, 4 males; 21 Cushing’s...
The aim of the study was to evaluate patients with Cushing’s syndrome the coronary flow reserve (CFR), an index of coronary microvascular function. Fifteen newly diagnosed patients with Cushing’s syndrome (1 male/14 females; mean age 45 ± 11 years), were selected for having no clinical evidence of ischemic heart disease. Twelve patients had pituitary-dependent Cushing’s disease and three had an adrenal...
Riassunto La prescrizione off-label dei farmaci è un tema di solito trattato da farmacologi o legali. Per recuperare la dovuta attenzione dei medici è invece necessario ricordare che la sicurezza del paziente rappresenta la storica “mission” della professione medica. Solo spronando tale orgoglio culturale si può pensare di recuperare il senso e l’applicazione della relativa normativa, che solitamente...
A large body of in vitro evidence shows that cytokines influence the hypothalamic–pituitary–adrenal axis both in physiological conditions and in Cushing’s disease (CD). In order to study in vivo the role of intrapituitary cytokines in CD, we assayed two cytokines known for their action on the pituitary, i.e. interleukin-1 beta (IL-1β) and interleukin-6 (IL-6), and also soluble interleukin-6 receptor...
The effect of a surgical cure of hypercortisolism on hypertension in 54 patients with Cushing's syndrome was assessed. The correlation between preoperative duration of hypertension and posttreatment blood pressure was significant (P < .01). Restoration of normal cortisol was associated with blood pressure normalization in 39 out of 54 cases. Duration of hypertension of patients with normalized...
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