Search results for: Liat Drucker

Items from 1 to 13 out of 13 results

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Placental supernatants’ enhancement of the metastatic potential of breast cancer cells: is estrogen receptor (ERα) essential for this phenomenon?

Michal Bar, Oded Komemi, Meir Pomeranz, Ami Fishman, more

Archives of Gynecology and Obstetrics > 2019 > 300 > 4 > 981-991

Purpose Pregnancy-associated breast cancer (PABC) is usually diagnosed at an advanced stage in comparison to non-pregnant women. The placenta secretes hormones and cytokines, which affect breast cancer progression. Previously, we demonstrated that human placental secretome facilitates the survival and migration of ERα+ breast cancer cells (BCCL), but pregnant women have a relatively high frequency...

article

Placenta‐conditioned extracellular matrix (ECM) activates breast cancer cell survival mechanisms: A key for future distant metastases

Oded Komemi, Gali Epstein Shochet, Meir Pomeranz, Ami Fishman, more

International Journal of Cancer > 144 > 7 > 1633 - 1644

The extracellular matrix (ECM) affects cancer cell characteristics. Inability of normal epithelial cells to attach to the ECM induces apoptosis (anoikis). Cancer cells are often anoikis resistant, a prerequisite for their metastatic spread. Previously we demonstrated that the placenta manipulates its surrounding ECM in a way that prevents breast cancer cells (BCCL) attachment and induces their motility...

article

First trimester human placenta prevents breast cancer cell attachment to the matrix: The role of extracellular matrix

Gali Epstein Shochet, Liat Drucker, Meir Pomeranz, Ami Fishman, more

Molecular Carcinogenesis > 56 > 1 > 62 - 74

The extracellular matrix (ECM) affects cancer cell characteristics. Its detachment from the ECM induces cell apoptosis, termed anoikis. Cancer cells can develop anoikis resistance, a necessary step for metastasis, by switching integrins, over‐expressing growth factor receptors, and inducing epithelial mesenchymal transition (EMT). The placenta is a non‐supportive microenvironment for cancer cells...

article

Heat shock protein-27 (HSP27) regulates STAT3 and eIF4G levels in first trimester human placenta

Gali Epstein Shochet, Oded Komemi, Dana Sadeh-Mestechkin, Meir Pomeranz, more

Journal of Molecular Histology > 2016 > 47 > 6 > 555-563

During placental implantation, cytotrophoblast cells differentiate to extravillous trophoblast (EVT) cells that invade from the placenta into the maternal uterine blood vessels. The heat shock protein-27 (HSP27), the signal transducer and activator of transcription-3 (STAT3) and the eukaryotic translation initiation factor 4E (EIF4E) are involved in regulating EVT cell differentiation/migration. EIF4E...

article

Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation

Oshrat Attar-Schneider, Victoria Zismanov, Liat Drucker, Maya Gottfried

Tumor Biology > 2016 > 37 > 4 > 4755-4765

Non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related death worldwide. Patients presenting with advanced-stage NSCLC have poor prognosis, while metastatic spread accounts for >70 % of patient’s deaths. The major advances in the treatment of lung cancer have brought only minor improvements in survival; therefore, novel strategic treatment approaches are urgently needed...

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Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma

Oshrat Attar-Schneider, Liat Drucker, Victoria Zismanov, Shelly Tartakover-Matalon, more

Cellular Signalling > 2014 > 26 > 9 > 1878-1887

Deregulation of protein synthesis is integral to the malignant phenotype and translation initiation is the rate limiting stage. Therefore, eIF4F translation initiation complex components are attractive therapeutic targets.Protein lysates of myeloma cells (cell lines/patients' bone marrow samples) untreated/treated with bevacizumab were assayed for eIF4GI expression, regulation (NQO1/proteosome dependent...

article

Placenta-breast cancer cell interactions promote cancer cell epithelial mesenchymal transition via TGFβ/JNK pathway

Gali Epstein Shochet, Shelly Tartakover-Matalon, Liat Drucker, Metsada Pasmanik-Chor, more

Clinical & Experimental Metastasis > 2014 > 31 > 8 > 961-975

Women diagnosed with pregnancy associated breast cancer often have advanced cancer with metastases and reduced expression of ERα compared to non-pregnant women. Nevertheless, metastases to the placenta are uncommon. Previously, we demonstrated that breast cancer cells (MCF-7/T47D) migrated from ex vivo human placental explant implantation sites. We aimed to analyze the effect of factors produced during...

article

749: Analyzing the effect of heat shock protein 27 on extravillous trophoblast differentiation and on eukaryotic translation initiation factor 4E expression

Dana Sadeh Mestechkin, Gali Epstein Shochet, Michael Lishner, Miki Pomeranz, more

American Journal of Obstetrics and Gynecology > 2014 > 210 > 1 Supplement > S368

article

ER homeostasis and motility of NSCLC cell lines can be therapeutically targeted with combined Hsp90 and HDAC inhibitors

Victoria Zismanov, Liat Drucker, Maya Gottfried

Pulmonary Pharmacology & Therapeutics > 2013 > 26 > 3 > 388-394

Lung cancer remains the most common cause of cancer-related death in the world for which novel systemic treatments are urgently needed.Protein homeostasis that regulates protein levels and their fold is critical for cancer cell proliferation and survival. A complex network of cellular organelles and signaling cascades is involved in control of protein homeostasis including endoplasmic reticulum (ER)...

article

Tetraspanins stimulate protein synthesis in myeloma cell lines

Victoria Zismanov, Liat Drucker, Oshrat Attar‐Schneider, Shelly Tartakover Matalon, more

Journal of Cellular Biochemistry > 113 > 7 > 2500 - 2510

Intensive protein synthesis is a unique and differential trait of multiple myeloma (MM) cells. Previously we showed that tetraspanin (CD81, CD82) overexpression in MM cell lines attenuated Akt/mTOR cascades, activated UPR, and caused autophagic death, suggesting breach of protein homeostasis. Here, we explored the role of protein synthesis in the tetraspanin‐induced MM cell death. Contrary to attenuation...

article

188: Analyzing the involvement of heat shock protein 27 in placental implantation and its effect on eukaryotic translation initiation factor 4E expression

Dana Sadeh-Mestechkin, Shelly Tartakover Matalon, Meir Pomeranz, Ami Fishman, more

American Journal of Obstetrics and Gynecology > 2012 > 206 > 1 Supplement > S95-S96

article

Tetraspanins affect myeloma cell fate via Akt signaling and FoxO activation

Michael Lishner, Victoria Zismanov, Tali Tohami, Shelly Tartakover-Matalon, more

Cellular Signalling > 2008 > 20 > 12 > 2309-2316

Myeloma cell interface with microenvironmental components is critical to cell growth and survival and perceived as a major obstacle for effective disease treatment. Hence, molecules that facilitate cell–cell and cell–ECM interactions are particularly important. We have previously shown that re-expression of membranal microdomain organizers, tetraspanins CD81 and CD82, caused myeloma cell death. Herein...

article

Cytokeratin 20 as a Biomarker of Gestational Trophoblastic Disease: Diagnostic and Prognostic Significance

Rodica Stackievicz, Liat Drucker, Ruth Zemer, Ami Klein, more

Gynecologic Oncology > 2002 > 87 > 1 > 34-38

Objectives. This study was designed to examine whether cytokeratin 20 (CK20) is expressed in molar pregnancies and may therefore be used in the diagnosis of gestational trophoblastic disease (GTD). The potential of CK20 expression in predicting the evolution and the prognosis of the different subtypes of GTD was also assessed.Methods. A total of 48 samples were studied for CK20 expression by RT-PCR...

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