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Conclusion The pharmacokinetics of DX-8951f were greatly improved by DE-310 with the extremely longer retention in bloodstream, resulting in the preferential tumor-targeting, and with the slow release appropriate to camptothecin analog DX-8951f in tumor tissue. On the basis of the pharmacokinetic improvement, DE-310 exhibited enhanced antitumor effects with reduced toxicities by a single and low dose,...
Purpose. We have previously shown Glc-S-C7-Me (octyl β-D-thioglucoside) exhibits renal targeting potential in vivo in addition to its specific binding to the renal membrane fraction in vitro. Thus, 'alkylglycoside' is considered to be a novel targeting vector for the kidney (1,2). The present study is designed to clarify the structural requirements for alkylglycoside as a renal targeting vector...
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