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This article reports a microfluidic device for the generation of stable, steady-state, user-defined concentration profiles for the long-term maintenance of stable diffusion gradients. The microinstrument allows both dynamic temporal and dynamic spatial control over user-defined concentrations and concentration gradients of multiple chemicals. With this device, one can create an in vitro environment...
A microneedle array has been fabricated and applied to the measurement of transdermal skin potentials in human subjects. Potential changes were recorded in the vicinity of superficial wounds, confirming the generation of a lateral electric field in human skin. The measured electric field decays with distance from the wound edge, and is directed towards the wound. The measurement of endogenous fields...
The effects of the anticonvulsant gabapentin were measured on vision and eye movements in three patients with acquired pendular nystagmus. In two patients, the nystagmus was associated with multiple sclerosis and, in the other, it followed brainstem stroke. A single oral 600 mg dose of gabapentin produced improvement of vision due to changes in ocular oscillations in all three patients. The effect...
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