Search results for: Makoto Ohno

Items from 1 to 20 out of 38 results

article

Central nervous system sarcoma with ATXN1::DUX4 fusion expands the concept of CIC‐rearranged sarcoma

Kaishi Satomi, Makoto Ohno, Takashi Kubo, Mai Honda‐Kitahara, more

Genes, Chromosomes and Cancer > 61 > 11 > 683 - 688

CIC‐rearranged sarcoma is a high‐grade sarcoma, most often harboring CIC::DUX4 fusion, and is characterized by a distinct round cell histology, co‐expression of ETV4 and WT1, and a specific DNA methylation class. Herein, we report a brain tumor with ATXN1::DUX4 that had an indistinguishable phenotype and DNA methylation profile from CIC‐rearranged sarcoma. A 40‐year‐old man presented with a 5 cm hemorrhagic...

article

Survival benefits of hypofractionated radiotherapy combined with temozolomide or temozolomide plus bevacizumab in elderly patients with glioblastoma aged ≥ 75 years

Makoto Ohno, Yasuji Miyakita, Masamichi Takahashi, Hiroshi Igaki, more

Radiation Oncology > 2019 > 14 > 1 > 1-10

Background and purpose The purpose of this study was to evaluate the outcomes of elderly patients (aged ≥75 years) with newly diagnosed glioblastoma (GBM), who were treated with hypofractionated radiotherapy comprising 45 Gy in 15 fractions combined with temozolomide (TMZ) or TMZ and bevacizumab (TMZ/Bev). Materials and methods Between October 2007 and August 2018, 30 patients with GBM aged ≥75...

article

Frequent false‐negative immunohistochemical staining with IDH1 (R132H)‐specific H09 antibody on frozen section control slides: a potential pitfall in glioma diagnosis

Akihiko Yoshida, Kaishi Satomi, Makoto Ohno, Yuko Matsushita, more

Histopathology > 74 > 2 > 350 - 354

Aims Intraoperative consultation using frozen sections (FSs) is an integral component of clinical practice. As a quality control measure, FS diagnosis is subsequently compared with the findings on a FS control slide. These control slides can be used for immunohistochemistry, and the immunohistochemical performance in FS controls is known to be antibody‐dependent. Isocitrate dehydrogenase (IDH) is...

article

Radiological characteristics based on isocitrate dehydrogenase mutations and 1p/19q codeletion in grade II and III gliomas

Takahiro Yamauchi, Makoto Ohno, Yuko Matsushita, Masamichi Takahashi, more

Brain Tumor Pathology > 2018 > 35 > 3 > 148-158

The radiological features of lower-grade gliomas (LGGs) classified according to isocitrate dehydrogenase (IDH) mutations and codeletion of chromosomal arms 1p and 19q (1p/19q codeletion) remain unclear. We aimed to systematically characterize the radiological features of molecularly classified LGGs using IDH and 1p/19q codeletion statuses. One hundred and one LGGs were re-classified into 36 tumors...

article

Erratum to: Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas

Hideyuki Arita, Yoshitaka Narita, Yuko Matsushita, Shintaro Fukushima, more

Brain Tumor Pathology > 2018 > 35 > 1 > 46-47

The online version of the original article can be found at https://doi.org/10.1007/s10014-014-0186-0 .

article

Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma

Taishi Nakamura, Satoshi Yamashita, Kazutaka Fukumura, Jun Nakabayashi, more

Acta Neuropathologica > 2017 > 133 > 2 > 321-324

Electronic supplementary material The online version of this article (doi: 10.1007/s00401-016-1664-8 ) contains supplementary material, which is available to authorized users.

article

The necessity of long-term follow-up including spinal examination after successful initial treatment of intracranial germinoma: case reports

Makoto Ohno, Yoshitaka Narita, Yasuji Miyakita, Soichiro Shibui

Child's Nervous System > 2016 > 32 > 3 > 547-551

Introduction Intracranial germinomas seldom recur at spinal space following whole-brain or whole-ventricular (WV) radiotherapy. The majority of the spinal recurrence takes place within 5 years after treatment; therefore, late spinal failure beyond 5 years after successful initial treatment is rare. Case presentations We describe the cases of two patients with intracranial germinoma, who developed...

article

“Comet tail sign”: A pitfall of post-gadolinium magnetic resonance imaging findings for metastatic brain tumors

Koichi Mitsuya, Yoko Nakasu, Yoshitaka Narita, Satoshi Nakasu, more

Journal of Neuro-Oncology > 2016 > 127 > 3 > 589-595

A highly enhanced cap attached to the surface of metastatic tumors in the brain parenchyma is occasionally encountered on magnetic resonance (MR) images. This atypical enhanced cap tends to occur in severe peritumoral edema and may produce the characteristic bulge of a metastatic mass lesion termed the “comet tail sign” (CTS). The purpose of this study was to demonstrate the features of the CTS using...

article

A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas

Hideyuki Arita, Kai Yamasaki, Yuko Matsushita, Taishi Nakamura, more

Acta Neuropathologica Communications > 2016 > 4 > 1 > 1-14

The prognostic impact of TERT mutations has been controversial in IDH-wild tumors, particularly in glioblastomas (GBM). The controversy may be attributable to presence of potential confounding factors such as MGMT methylation status or patients’ treatment. This study aimed to evaluate the impact of TERT status on patient outcome in association with various factors in a large series of adult diffuse...

article

Revisiting TP53 Mutations and Immunohistochemistry—A Comparative Study in 157 Diffuse Gliomas

Hirokazu Takami, Akihiko Yoshida, Shintaro Fukushima, Hideyuki Arita, more

Brain Pathology > 25 > 3 > 256 - 265

The association between p53 immunohistochemistry and TP53 mutation status has been controversial. The present study aims to re‐evaluate the efficacy of p53 immunohistochemistry to predict the mutational status of TP53. A total of 157 diffuse gliomas (World Health Organization grades II–IV) were assessed by exon‐by‐exon DNA sequencing from exon 4 through 10 of TP53 using frozen tissue samples. Immunohistochemistry...

article

Multinodular and vacuolating neuronal tumor of the cerebrum

Shintaro Fukushima, Akihiko Yoshida, Yoshitaka Narita, Hideyuki Arita, more

Brain Tumor Pathology > 2015 > 32 > 2 > 131-136

Multinodular and vacuolating neuronal tumors of the cerebrum (MVNT) are superficial neuronal tumors in adults that were first documented in 2013. Herein, we report a case of MNVT involving a 37-year-old man who presented with an epileptogenic, superficial solid lesion in the left parietal lobe. Histomorphology of the resected specimen was characterized by nodular lesions with vacuolation. Nodules...

article

Intraparenchymal, primary central nervous system lymphoma of low-grade B cell malignancy: a case report with review of the literature on therapeutic consideration

Ryosuke Tomio, Hikaru Sasaki, Shigemichi Hirose, Takayuki Shimizu, more

International Cancer Conference Journal > 2015 > 4 > 2 > 73-80

Intraparenchymal, low-grade primary central nervous system lymphomas are rare entities. We present a case of HIV negative, non-dural, low-grade primary central nervous system B cell lymphoma. A 35 year-old man presented with memory and visual disturbance. Magnetic resonance imaging demonstrated a high intensity lesion on T2 weighted images in right medial temporal lobe to basal ganglia, with...

article

Erratum to: Intraparenchymal, primary central nervous system lymphoma of low-grade B cell malignancy: a case report with review of the literature on therapeutic consideration

Ryosuke Tomio, Hikaru Sasaki, Shigemichi Hirose, Takayuki Shimizu, more

International Cancer Conference Journal > 2015 > 4 > 2 > 81-82

article

Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas

Hideyuki Arita, Yoshitaka Narita, Yuko Matsushita, Shintaro Fukushima, more

Brain Tumor Pathology > 2015 > 32 > 1 > 22-30

Assessment of the mutational status of the isocitrate dehydrogenase 1/2 (IDH1/2) gene has become an integral part of the standard diagnostic procedure and, therefore, needs to be accurate. This may, however, be compromised by various factors including the method of analysis and a low tumor cell content. We have developed a rapid, sensitive and robust assay to detect all types of mutation in either...

article

Short communication: sclerosing meningioma in the deep sylvian fissure

Shintaro Fukushima, Yoshitaka Narita, Motoki Yonezawa, Makoto Ohno, more

Brain Tumor Pathology > 2014 > 31 > 4 > 289-292

Sclerosing meningioma is a rare type of meningeal tumor with extensive collagen depositions. Deep sylvian meningioma, a tumor that is unattached to the dura mater, is also unusual. The biological activity of both is controversial, as are therapeutic strategies. A heterogeneous contrast-enhanced mass in the right sylvian fissure of a 10-year-old boy with a 3-year history of epilepsy was identified...

article

Risk factors for early death after surgery in patients with brain metastases: reevaluation of the indications for and role of surgery

Hideyuki Arita, Yoshitaka Narita, Yasuji Miyakita, Makoto Ohno, more

Journal of Neuro-Oncology > 2014 > 116 > 1 > 145-152

Surgical resection remains an important option for the treatment of brain metastases despite recent advancements in radiotherapy and systemic therapy. When selecting surgical candidates, it is important to exclude terminal cases who will receive neither a survival benefit nor an improvement in their quality of life. We reviewed a total of 264 surgical cases of brain metastases and analyzed the clinical...

article

Usefulness of a glass-free medical three-dimensional autostereoscopic display in neurosurgery

Yoshitaka Narita, Shinsuke Tsukagoshi, Masahiro Suzuki, Yasuji Miyakita, more

International Journal of Computer Assisted Radiology and Surgery > 2014 > 9 > 5 > 905-911

Purpose Many stereoscopic displays require glasses that are awkward or inappropriate for use in a neurosurgical operating room. A glass-free three-dimensional autostereoscopic display (3DAD) monitor was developed and tested for neurosurgical applications. Methods Our 3DAD system uses images acquired from nine directions projected into the viewer’s eyes through 1,280 lenticular lenses ( $$\text...

article

A case of more than 20 years survival with glioblastoma, and development of cavernous angioma as a delayed complication of radiotherapy

Shintaro Fukushima, Yoshitaka Narita, Yasuji Miyakita, Makoto Ohno, more

Neuropathology > 33 > 5 > 576 - 581

Glioblastoma (GBM) is the most common malignant CNS neoplasm, the prognosis of which remains poor even after multidisciplinary treatment. The 5‐year overall survival rate of GBM is less than 10% and has remained unchanged for more than 50 years. Because GBM patients rarely survive over a decade, only very few cases of delayed complications caused by therapy have been reported. Here, we report the...

article

Management of glioblastoma in an NF1 patient with moyamoya syndrome: a case report

Hideyuki Arita, Yoshitaka Narita, Makoto Ohno, Yasuji Miyakita, more

Child's Nervous System > 2013 > 29 > 2 > 341-345

Introduction Glioma and moyamoya syndrome are both potential complications of neurofibromatosis type 1 (NF1). Here, we report the first case of NF1 concomitantly presenting with glioblastoma 10 years after surgical treatment of moyamoya syndrome. Case report A 14-year-old boy with NF1 was incidentally diagnosed by magnetic resonance imaging (MRI) with a thalamic tumor during a follow-up for moyamoya...

article

Secondary glioblastomas with IDH1/2 mutations have longer glioma history from preceding lower-grade gliomas

Makoto Ohno, Yoshitaka Narita, Yasuji Miyakita, Yuko Matsushita, more

Brain Tumor Pathology > 2013 > 30 > 4 > 224-232

Isocitrate dehydrogenase (IDH)1/2 mutations have been proposed as a genetic marker for secondary glioblastoma (sGBM). This study aimed to evaluate the impact of the IDH1/2 mutations on the clinical course and genetic alterations of sGBMs, which histopathologically progressed from lower-grade gliomas. We investigated 18 sGBMs, including 8 sGBMs with IDH1/2 mutations (sGBM-Mut) and 10 with wild-type...

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INFONA - science communication portal

Search results for: Makoto Ohno

Central nervous system sarcoma with ATXN1::DUX4 fusion expands the concept of CIC‐rearranged sarcoma

Survival benefits of hypofractionated radiotherapy combined with temozolomide or temozolomide plus bevacizumab in elderly patients with glioblastoma aged ≥ 75 years

Frequent false‐negative immunohistochemical staining with IDH1 (R132H)‐specific H09 antibody on frozen section control slides: a potential pitfall in glioma diagnosis

Radiological characteristics based on isocitrate dehydrogenase mutations and 1p/19q codeletion in grade II and III gliomas

Erratum to: Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas

Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma

The necessity of long-term follow-up including spinal examination after successful initial treatment of intracranial germinoma: case reports

“Comet tail sign”: A pitfall of post-gadolinium magnetic resonance imaging findings for metastatic brain tumors

A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas

Revisiting TP53 Mutations and Immunohistochemistry—A Comparative Study in 157 Diffuse Gliomas

Multinodular and vacuolating neuronal tumor of the cerebrum

Intraparenchymal, primary central nervous system lymphoma of low-grade B cell malignancy: a case report with review of the literature on therapeutic consideration

Erratum to: Intraparenchymal, primary central nervous system lymphoma of low-grade B cell malignancy: a case report with review of the literature on therapeutic consideration

Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas

Short communication: sclerosing meningioma in the deep sylvian fissure

Risk factors for early death after surgery in patients with brain metastases: reevaluation of the indications for and role of surgery

Usefulness of a glass-free medical three-dimensional autostereoscopic display in neurosurgery

A case of more than 20 years survival with glioblastoma, and development of cavernous angioma as a delayed complication of radiotherapy

Management of glioblastoma in an NF1 patient with moyamoya syndrome: a case report

Secondary glioblastomas with IDH1/2 mutations have longer glioma history from preceding lower-grade gliomas

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