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An implantable bi-directional brain-machine interface (BMI) prototype is presented. With sensing, algorithm, wireless telemetry, and stimulation therapy capabilities, the system is designed for chronic studies exploring closed-loop and diagnostic opportunities for neuroprosthetics. In particular, we hope to enable fundamental chronic research into the physiology of neurological disorders, define key...
This paper discusses the challenges and opportunities designing technology for deep brain stimulation (DBS). DBS is currently approved for the treatment of movement disorders such as Parkinson Disease, essential tremor and dystonia, and a number of studies are underway to determine its clinical efficacy for the treatment of epilepsy, treatment resistant depression, and obsessive compulsive disorder...
This paper describes a prototype architecture that tracks the power fluctuations in discrete frequency bands for a broad spectrum of neuronal biomarkers. The circuit merges chopper-stabilization with heterodyne signal processing to construct a low-noise amplifier with highly programmable, robust filtering characteristics. It is concluded that in our application, the area and modest noise penalty are...
This paper describes an amplification and spectral processing IC for extracting key bioelectrical signals, or ldquobiomarkersrdquo, which are expressed in the brain's field potentials. The intent is to explore using these biomarkers to drive prosthetic actuators or titrate therapy devices such as a deep-brain neurostimulator. The prototype IC uses 5 muW/channel to resolve signals on the order of 1...
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