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Rationale Two biomarkers: concentration ratio of O-desmethylvenlafaxine/venlafaxine and concentration sum of venlafaxine + O-desmethylvenlafaxine were adopted to indicate venlafaxine responses, but neither is validated. Objectives To evaluate the ability of two biomarkers in reflecting venlafaxine pharmacokinetic variations, and to further examine their relationship with venlafaxine treatment outcomes...
This study aimed to analyze the economic effect of the red sea bream Pagrus major offshore aquaculture production system in Korea. Based on the data collected, revenue and expenses throughout the culture period were calculated, and the net present value and internal rate of return of the ten-year cash flow and cash outflow were estimated in order to determine the economic validity of red sea bream...
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