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Natural products continue to be a useful source of new leads for the pharmaceutical industry. Actinomycetes are prolific producers of natural products and one strategy to increase the possibility of discovering novel chemical entities is to screen actinomycetes considered `rare' in the environment and previously under-represented in natural product screening collections. We describe a method using...
Traditionally, natural products have been important sources of new leads for the pharmaceutical industry , but with discovery rates of novel structural classes in decline , the need to bioprospect alternate sources of chemical diversity is evident. Microbial genome sequencing projects have revealed the presence of 'silent' biosynthetic gene clusters where there is no current detectable product . Likewise,...
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