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We address the problem of estimating the degree to which the evolutionary history of a set of molecular sequences violates a strong molecular clock hypothesis. We quantify this deviation formally, by defining the “stretch” of a model tree with respect to the underlying ultrametric tree (indicated by time). We then define the “minimum stretch” of a dataset for a tree and show how this can be computed...
We present the results of a large-scale experimental study of quartet-based methods (quartet cleaning and puzzling) for phylogeny reconstruction. Our experiments include a broad range of problem sizes and evolutionary rates, and were carefully designed to yield statistically robust results despite the size of the sample space. We measure outcomes in terms of numbers of edges of the true tree correctly...
It has recently been shown that UDP-glucose is a potent agonist of the orphan G-protein-coupled receptor (GPCR) KIAA0001. Here we report cloning and analysis of the rat and mouse orthologs of this receptor. In accordance with GPCR nomenclature, we have renamed the cDNA clone, KIAA0001, and its orthologs GPR105 to reflect their functionality as G-protein-coupled receptors. The rat and mouse orthologs...
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