Search results for: K. Kaibuchi
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Genes, Brain and Behavior > 17 > 8 > n/a - n/a
Disrupted‐in‐schizophrenia 1 (Disc1) is a key molecular driver for the biology of mental diseases. In order to investigate its role in brain function, we previously generated mice lacking exons 2 and 3 of Disc1 on a C57BL/6J genetic background (Disc1Δ2‐3/Δ2‐3 mice), which have a deficiency of the full‐length Disc1 protein. In the present study, we examined the role of Disc1 in cognitive function using...
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A mature neuron is typically polarized with a single long axon and several dendrites. After the birth and differentiation of a neuron, a neuron breaks its previous symmetry and establishes an axon and dendrites. Neuronal polarization occurs when one of the multiple immature neurites emerging from the cell body elongates rapidly. This neurite becomes the axon, whereas the remaining immature neurites...
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Journal of Human Genetics > 2001 > 46 > 1 > 21-25
Abstract Our previous comparative genomic hybridization (CGH) study revealed a novel amplified region at 15q26 in two cell lines established from diffuse types of gastric cancer (GC). In this amplified region, FES and IGF1R, known targets on 15q26, were located telomeric to the amplicon in the two cell lines, HSC39 and 40A, suggesting that another tumor-associated gene exists in this region. While...
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Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. To elucidate the role of ROCK II in human disease, we have cloned a 4363-bp cDNA encoding human ROCK II. Sequencing...
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Myosin phosphatase target subunit 1 (MYPT1), which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho, as previously shown (K. Kimura,et al.,1996,Science273: 245–248). To understand the role of MYPT1 in the regulation of the cytoskeleton...
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Restorative Neurology and Neuroscience > 1995 > 9 > 1 > 46
In the mammalian central nervous system (CNS), multipotential neural stem cells in the developing neuroepithelium generate the three major types of neural cells, namely neurons, astrocytes, and oligodendrocytes.To explore the molecular mechanisms controlling proliferation and differentiation of the neural stem cells, we have established clonal cell lines (named MNS cell lines) from the embryonic day...
