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The P4 ATPase family of P-type ATPases is of especial interest, since the main function of P4 ATPases is the translocation of phospholipids, phosphatidylserine in particular, from the outer monolayer of the plasma membrane to the inner one. P4 ATPase isoforms are redundant to some extent, but structural defects of certain isoforms can still lead to rather severe pathologies at the whole-organism level...