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As the foundations of the 6th generation aircraft are being established, they are being designed to provide more capabilities under architectural constraints that may lead to thermal and power limitations. As the complexity grows, the traditional systems engineering methods of verification and validation (V&V) have shown deficiencies that result in cost overruns for aircraft development. In order...
Transverse aortic constriction (TAC) is used as a model of left ventricular hypertrophy and failure; however, there is extensive variability in the hypertrophic response. In 43 mice that underwent TAC with a 7–0 polypropylene suture, 13 were identified by echocardiography with initial LV hypertrophy that halted or regressed over time. Post–mortem examination on 7 of these mice found the constricting...
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