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Many mammalian β‐tubulin mutations that confer paclitaxel resistance have been characterized, but little is currently known about the role of α‐tubulin mutations in drug resistance. Previous studies using two‐dimensional gel electrophoresis showed that α‐tubulin mutations occur with a frequency equal to β‐tubulin mutations among CHO cells selected for resistance to paclitaxel but the identities of...
Purpose Previous research showed that mutations in β1-tubulin are frequently involved in paclitaxel resistance but the question of whether the mutations are restricted by cell-type specific differences remains obscure. Methods To circumvent cellular constraints, we randomly mutagenized β-tubulin cDNA, transfected it into CHO cells, and selected for paclitaxel resistance. Results A total of 26...
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