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Hintergrund. Matrixmetalloproteinasen (MMP) sind Endopeptidasen, die Extrazellulrmatrix degradieren knnen und eine wichtige Rolle bei Invasion und Metastasierung von Malignomen spielen sollen. Die Expression der Kollagenase-3, auch MMP-13 genannt, konnte bereits bei Plattenepithelkarzinomen im Kopf-Hals-Bereich nachgewiesen werden. Ungeklrt ist ihre Bedeutung beim Metastasierungsprozess. Patienten...
Abstract. We describe a novel methodological approach for inducing cold lesion in the mouse as a model of human cortical contusion trauma. To validate its reproducibility and reliability, dexamethasone (Dxm) was repeatedly applied to demonstrate possible antioedematous drug effects. Following the induction of anaesthesia with halothane, the dura was exposed via trephination. Using a micromanipulator...
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