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Abstract. Purpose: In this study we investigated the effect of pentoxifylline (PTX) on tumor-induced neovascularization as well as on different steps involved in the angiogenic process. Methods: To assess angiogenesis inhibition, we injected intradermally (i.d.) 106 B16-F10 melanoma cells into C57BL/6J mice which were subsequently intraperitoneally (i.p.) inoculated with PTX or saline. On day7 the...