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Over the past 15 years, there have been various attempts to rationally develop selective ligands for serotonin 5-HT2C receptor subtypes. To this end, the studies performed by researchers at GlaxoSmithKline have led to the identification of several potent and selective 5-HT2C receptor antagonists characterized by indole- or indoline-containing structure. The large body of data on antagonists has allowed...