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AbstractWe describe on a 3-year-old child referred for evaluation and therapy of a cerebral vascular accident with residual hemiplegia and partial epilepsy. Metabolic investigations initially showed normal urinary organic acids as well as normal blood and urinary amino acids. Blood carnitine fractions had been pathological and a secondary carnitine deficiency was diagnosed and treated by oral l-carnitine...
In rat liver homogenates fortified with the appropriate cofactors (ATP and CoA), valproic acid induced H 2 O 2 production rates by far lower than those recorded on the straight medium-chain fatty acid n-octanoic acid. Using directly the CoA esters of these carboxylic acids as substrates for the rat liver H 2 O 2 -generating enzyme activities, valproyl-CoA, and n-octanoyl-CoA...
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